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Extracellular matrix production in vitro in cartilage tissue engineering

Overview of attention for article published in Journal of Translational Medicine, April 2014
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Title
Extracellular matrix production in vitro in cartilage tissue engineering
Published in
Journal of Translational Medicine, April 2014
DOI 10.1186/1479-5876-12-88
Pubmed ID
Authors

Jie-Lin Chen, Li Duan, Weimin Zhu, Jianyi Xiong, Daping Wang

Abstract

Cartilage tissue engineering is arising as a technique for the repair of cartilage lesions in clinical applications. However, fibrocartilage formation weakened the mechanical functions of the articular, which compromises the clinical outcomes. Due to the low proliferation ability, dedifferentiation property and low production of cartilage-specific extracellular matrix (ECM) of the chondrocytes, the cartilage synthesis in vitro has been one of the major limitations for obtaining high-quality engineered cartilage constructs. This review discusses cells, biomaterial scaffolds and stimulating factors that can facilitate the cartilage-specific ECM production and accumulation in the in vitro culture system. Special emphasis has been put on the factors that affect the production of ECM macromolecules such as collagen type II and proteoglycans in the review, aiming at providing new strategies to improve the quality of tissue-engineered cartilage.

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The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 132 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Portugal 1 <1%
Malaysia 1 <1%
Brazil 1 <1%
United Kingdom 1 <1%
Denmark 1 <1%
Unknown 127 96%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 31 23%
Student > Master 26 20%
Student > Bachelor 19 14%
Researcher 16 12%
Other 5 4%
Other 15 11%
Unknown 20 15%
Readers by discipline Count As %
Engineering 32 24%
Agricultural and Biological Sciences 19 14%
Biochemistry, Genetics and Molecular Biology 17 13%
Medicine and Dentistry 17 13%
Materials Science 8 6%
Other 19 14%
Unknown 20 15%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 April 2014.
All research outputs
#20,228,193
of 22,753,345 outputs
Outputs from Journal of Translational Medicine
#3,305
of 3,977 outputs
Outputs of similar age
#193,108
of 226,065 outputs
Outputs of similar age from Journal of Translational Medicine
#36
of 63 outputs
Altmetric has tracked 22,753,345 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,977 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.5. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 226,065 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 63 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.