Title |
Extracellular matrix production in vitro in cartilage tissue engineering
|
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Published in |
Journal of Translational Medicine, April 2014
|
DOI | 10.1186/1479-5876-12-88 |
Pubmed ID | |
Authors |
Jie-Lin Chen, Li Duan, Weimin Zhu, Jianyi Xiong, Daping Wang |
Abstract |
Cartilage tissue engineering is arising as a technique for the repair of cartilage lesions in clinical applications. However, fibrocartilage formation weakened the mechanical functions of the articular, which compromises the clinical outcomes. Due to the low proliferation ability, dedifferentiation property and low production of cartilage-specific extracellular matrix (ECM) of the chondrocytes, the cartilage synthesis in vitro has been one of the major limitations for obtaining high-quality engineered cartilage constructs. This review discusses cells, biomaterial scaffolds and stimulating factors that can facilitate the cartilage-specific ECM production and accumulation in the in vitro culture system. Special emphasis has been put on the factors that affect the production of ECM macromolecules such as collagen type II and proteoglycans in the review, aiming at providing new strategies to improve the quality of tissue-engineered cartilage. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Portugal | 1 | <1% |
Malaysia | 1 | <1% |
Brazil | 1 | <1% |
United Kingdom | 1 | <1% |
Denmark | 1 | <1% |
Unknown | 127 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 31 | 23% |
Student > Master | 26 | 20% |
Student > Bachelor | 19 | 14% |
Researcher | 16 | 12% |
Other | 5 | 4% |
Other | 15 | 11% |
Unknown | 20 | 15% |
Readers by discipline | Count | As % |
---|---|---|
Engineering | 32 | 24% |
Agricultural and Biological Sciences | 19 | 14% |
Biochemistry, Genetics and Molecular Biology | 17 | 13% |
Medicine and Dentistry | 17 | 13% |
Materials Science | 8 | 6% |
Other | 19 | 14% |
Unknown | 20 | 15% |