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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Role of estrogen in hepatocellular carcinoma: is inflammation the key?
|
|---|---|
| Published in |
Journal of Translational Medicine, April 2014
|
| DOI | 10.1186/1479-5876-12-93 |
| Pubmed ID | |
| Authors |
Liang Shi, Yili Feng, Hui Lin, Rui Ma, Xiujun Cai |
| Abstract |
Hepatocellular carcinoma (HCC) is one of the most common malignancies worldwide and accounts for the third-leading cause of cancer-related deaths. Over the past decades, advances have been made in the field of surgery, but effective treatment of HCC is lacking. Due to a marked male predominance in morbidity and mortality in HCC patients, it has long been considered that sex hormones play a role in HCC development. Recently estrogen has been proven to exert protective effects against HCC through IL-6 restrictions, STAT3 inactivation and tumour-associated macrophage inhibition. While IL-6-dependent STAT3 activation is considered a key event in inflammation-induced liver cancer, the anti-inflammation effect of estrogen is well documented. The roles of the estrogen receptor and aromatase and interactions between microRNAs and estrogen in HCC have been investigated. In this review, we present a novel model to elucidate the mechanism of estrogen-mediated inhibition of HCC development through an anti-inflammation effect and provide new insights into the roles of estrogen in liver disease. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Hungary | 1 | 33% |
| Unknown | 2 | 67% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 116 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | <1% |
| United States | 1 | <1% |
| Denmark | 1 | <1% |
| Germany | 1 | <1% |
| Unknown | 112 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 27 | 23% |
| Researcher | 19 | 16% |
| Student > Bachelor | 15 | 13% |
| Student > Master | 8 | 7% |
| Student > Doctoral Student | 6 | 5% |
| Other | 17 | 15% |
| Unknown | 24 | 21% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 30 | 26% |
| Agricultural and Biological Sciences | 20 | 17% |
| Biochemistry, Genetics and Molecular Biology | 18 | 16% |
| Pharmacology, Toxicology and Pharmaceutical Science | 5 | 4% |
| Chemistry | 3 | 3% |
| Other | 10 | 9% |
| Unknown | 30 | 26% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 December 2014.
All research outputs
#15,299,491
of 22,753,345 outputs
Outputs from Journal of Translational Medicine
#2,234
of 3,977 outputs
Outputs of similar age
#134,727
of 228,038 outputs
Outputs of similar age from Journal of Translational Medicine
#27
of 66 outputs
Altmetric has tracked 22,753,345 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,977 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.5. This one is in the 31st percentile – i.e., 31% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 228,038 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 31st percentile – i.e., 31% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 66 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 56% of its contemporaries.