Title |
Excessive centrosome abnormalities without ongoing numerical chromosome instability in a Burkitt's lymphoma
|
---|---|
Published in |
Molecular Cancer, September 2003
|
DOI | 10.1186/1476-4598-2-30 |
Pubmed ID | |
Authors |
Stefan Duensing, Benjamin H Lee, Paola Dal Cin, Karl Münger |
Abstract |
Numerical and structural centrosome abnormalities are detected in various human malignancies and have been implicated in the formation of multipolar mitoses, chromosome missegregation, and chromosomal instability. Despite this association between centrosome abnormalities and cancerous growth, a causative role of centrosome aberrations in generating chromosomal instability and aneuploidy has not been universally established. We report here excessive numerical and structural centrosome abnormalities in a malignant Burkitt's lymphoma harboring the characteristic t(8;14) chromosomal translocation. Using conventional karyotyping and fluorescence in situ hybridization (FISH), we detected no signs of ongoing numerical chromosome instability, although the tumor displayed sporadic multipolar metaphases. These findings demonstrate that centrosome abnormalities are not a universal surrogate marker for chromosomal instability in malignant tumors. Moreover, our results suggest a model in which additional cellular alterations may be required to promote centrosome-related mitotic defects in tumor cells. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 21 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Professor > Associate Professor | 4 | 19% |
Researcher | 4 | 19% |
Student > Ph. D. Student | 4 | 19% |
Other | 2 | 10% |
Student > Doctoral Student | 2 | 10% |
Other | 2 | 10% |
Unknown | 3 | 14% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 9 | 43% |
Agricultural and Biological Sciences | 5 | 24% |
Medicine and Dentistry | 3 | 14% |
Environmental Science | 1 | 5% |
Unknown | 3 | 14% |