Title |
Prognostic effect of matrix metalloproteinase-9 in patients with resected Non small cell lung cancer
|
---|---|
Published in |
Journal of Cardiothoracic Surgery, March 2015
|
DOI | 10.1186/s13019-015-0248-3 |
Pubmed ID | |
Authors |
Chang Young Lee, Hyo Sup Shim, Seokkee Lee, Jin Gu Lee, Dae Joon Kim, Kyung Young Chung |
Abstract |
The role of tumor matrix metalloproteinase-9 (MMP-9) expression in non-small cell lung cancer (NSCLC) remains controversial. In this study, we investigated the prognostic value of tumor MMP-9 expression and other clinicopathologic factors in patients with completely resected NSCLC. This retrospective study included patients who underwent complete resection of pathological stage I-IIIA NSCLC at Severance Hospital, Seoul, Korea, between 1998 and 2009. Tumor samples of 417 patients were stained by immunohistochemistry, and the expression of MMP-9 in tumor cells was evaluated, using the median immunohistochemical score of 10 (range, 0-300) as the cut-off. Tumor MMP-9 expression was observed in 161 (38.6%) of 417 patients. Log-rank analysis showed a significant association of tumor MMP-9 expression with shortened disease-free survival (p = 0.01) but not with overall survival (p = 0.109). Multivariate analysis demonstrated that tumor MMP-9 expression was not an independent prognostic factor of recurrence (p = 0.142) or survival (p = 0.807). However, among patients with adenocarcinoma, tumor MMP-9 expression was associated with relapse (p = 0.003) and poor survival (p = 0.033). Furthermore, tumor MMP-9 expression was an independent prognostic indicator of relapse in patients with adenocarcinoma (p = 0.035). Among patients with NSCLC, tumor MMP-9 expression was associated with poor outcomes in those with adenocarcinoma, but not in those with squamous cell carcinoma. In addition, MMP-9 expression was identified as an independent predictor of relapse of completely resected lung adenocarcinoma. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 13 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 4 | 31% |
Researcher | 2 | 15% |
Professor | 1 | 8% |
Librarian | 1 | 8% |
Student > Bachelor | 1 | 8% |
Other | 1 | 8% |
Unknown | 3 | 23% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 4 | 31% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 15% |
Agricultural and Biological Sciences | 2 | 15% |
Immunology and Microbiology | 1 | 8% |
Biochemistry, Genetics and Molecular Biology | 1 | 8% |
Other | 0 | 0% |
Unknown | 3 | 23% |