Title |
Differences in age-related effects on brain volume in Down syndrome as compared to Williams syndrome and typical development
|
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Published in |
Journal of Neurodevelopmental Disorders, April 2014
|
DOI | 10.1186/1866-1955-6-8 |
Pubmed ID | |
Authors |
Mary Ellen I Koran, Timothy J Hohman, Courtney M Edwards, Jennifer N Vega, Jennifer R Pryweller, Laura E Slosky, Genea Crockett, Lynette Villa de Rey, Shashwath A Meda, Nathan Dankner, Suzanne N Avery, Jennifer U Blackford, Elisabeth M Dykens, Tricia A Thornton-Wells |
Abstract |
Individuals with Down Syndrome (DS) are reported to experience early onset of brain aging. However, it is not well understood how pre-existing neurodevelopmental effects versus neurodegenerative processes might be contributing to the observed pattern of brain atrophy in younger adults with DS. The aims of the current study were to: (1) to confirm previous findings of age-related changes in DS compared to adults with typical development (TD), (2) to test for an effect of these age-related changes in a second neurodevelopmental disorder, Williams syndrome (WS), and (3) to identify a pattern of regional age-related effects that are unique to DS. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United Kingdom | 3 | 60% |
Unknown | 2 | 40% |
Demographic breakdown
Type | Count | As % |
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Scientists | 2 | 40% |
Practitioners (doctors, other healthcare professionals) | 2 | 40% |
Members of the public | 1 | 20% |
Mendeley readers
Geographical breakdown
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Japan | 1 | 1% |
Unknown | 88 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 21 | 24% |
Student > Master | 15 | 17% |
Researcher | 11 | 12% |
Student > Bachelor | 7 | 8% |
Student > Postgraduate | 5 | 6% |
Other | 11 | 12% |
Unknown | 19 | 21% |
Readers by discipline | Count | As % |
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Psychology | 26 | 29% |
Neuroscience | 15 | 17% |
Medicine and Dentistry | 9 | 10% |
Biochemistry, Genetics and Molecular Biology | 4 | 4% |
Agricultural and Biological Sciences | 4 | 4% |
Other | 7 | 8% |
Unknown | 24 | 27% |