Title |
A method for high-throughput gene expression signature analysis
|
---|---|
Published in |
Genome Biology, July 2006
|
DOI | 10.1186/gb-2006-7-7-r61 |
Pubmed ID | |
Authors |
David Peck, Emily D Crawford, Kenneth N Ross, Kimberly Stegmaier, Todd R Golub, Justin Lamb |
Abstract |
Genome-wide transcriptional profiling has shown that different biologic states (for instance, disease and response to pharmacologic manipulation) can be recognized by the expression pattern of relatively small numbers of genes. However, the lack of a practical and cost-effective technology for detection of these gene expression 'signatures' in large numbers of samples has severely limited their exploitation in important medical and pharmaceutical discovery applications. Here, we describe a solution based on the combination of ligation-mediated amplification with an optically addressed microsphere and flow cytometric detection system. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Scientists | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 10 | 5% |
Italy | 1 | <1% |
Austria | 1 | <1% |
Czechia | 1 | <1% |
France | 1 | <1% |
Ukraine | 1 | <1% |
United Kingdom | 1 | <1% |
Belgium | 1 | <1% |
Canada | 1 | <1% |
Other | 0 | 0% |
Unknown | 200 | 92% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 68 | 31% |
Student > Ph. D. Student | 54 | 25% |
Professor > Associate Professor | 15 | 7% |
Professor | 13 | 6% |
Student > Master | 12 | 6% |
Other | 37 | 17% |
Unknown | 19 | 9% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 80 | 37% |
Biochemistry, Genetics and Molecular Biology | 39 | 18% |
Medicine and Dentistry | 26 | 12% |
Computer Science | 14 | 6% |
Chemistry | 13 | 6% |
Other | 19 | 9% |
Unknown | 27 | 12% |