Title |
Hypereosinophilia in childhood acute lymphoblastic leukaemia at diagnosis: report of 2 cases and review of the literature
|
---|---|
Published in |
Italian Journal of Pediatrics, April 2014
|
DOI | 10.1186/1824-7288-40-36 |
Pubmed ID | |
Authors |
Rosanna Parasole, Fara Petruzziello, Antonia De Matteo, Giovanna Maisto, Luisa Castelli, Maria Elena Errico, Giuseppe Menna, Vincenzo Poggi |
Abstract |
Hypereosinophilia as first clinical presentation has rarely been reported in paediatric acute lymphoblastic leukaemia. It is commonly associated with specific cytogenetic abnormalities. Although eosinophilia is considered a reactive, non-neoplastic epiphenomenon, it adversely affects patient outcomes, both in children and adults. We describe herewith two paediatric patients who had marked eosinophilia at onset of acute lymphoblastic leukaemia. We point out the importance of a correct differential diagnosis in persistent, unexplained peripheral hypereosinophilia. Clinicians should keep in mind that eosinophilia can be part of the overall pattern of acute leukaemia and therefore needs to be properly investigated. We also provide some recommendations for an appropriate approach to hypereosinophilia - related morbidities. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 3 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 33% |
Scientists | 1 | 33% |
Practitioners (doctors, other healthcare professionals) | 1 | 33% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 20 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 4 | 20% |
Student > Postgraduate | 3 | 15% |
Student > Ph. D. Student | 3 | 15% |
Other | 1 | 5% |
Lecturer | 1 | 5% |
Other | 3 | 15% |
Unknown | 5 | 25% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 10 | 50% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 10% |
Biochemistry, Genetics and Molecular Biology | 1 | 5% |
Unknown | 7 | 35% |