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Atrial time and voltage dispersion are both needed to predict new-onset atrial fibrillation in ischemic stroke patients

Overview of attention for article published in BMC Cardiovascular Disorders, July 2017
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Title
Atrial time and voltage dispersion are both needed to predict new-onset atrial fibrillation in ischemic stroke patients
Published in
BMC Cardiovascular Disorders, July 2017
DOI 10.1186/s12872-017-0631-1
Pubmed ID
Authors

Daniel Cortez, Maria Baturova, Arne Lindgren, Jonas Carlson, Yuri V. Shubik, Bertil Olsson, Pyotr G. Platonov

Abstract

Atrial fibrillation (AF) is a known risk factor for ischemic stroke. Electrocardiographic predictors of AF in population studies such as the Framingham Heart Study, as well as in hypertensive patients have demonstrated a predictive value of the P-wave duration for development of AF. QRS vector magnitude has had a predictive value in ventricular arrhythmia development. We aimed to assess the value of the three-dimensional P-wave vector magnitude and its relationship to P-wave duration for prediction of new-onset AF after ischemic stroke. First-ever ischemic stroke patients without AF at inclusion in the Lund Stroke Register were included. Measurements of P wave duration (Pd), QRS duration, corrected QT interval, and PQ interval were performed automatically using the University of Glasgow 12-lead ECG analysis algorithm. The P-wave vector magnitude (Pvm) was calculated automatically as the square root of the sum of the squared P-wave magnitudes in leads V6, II and one half of the P-wave amplitude in V2 ([Formula: see text]), based on the P-wave magnitude (Pvm) as defined by the visually transformed Kors' Quasi-orthogonal method. The median age was 73 (IQR 63-80) years at stroke onset (135 males, 92 females). Multivariate predictors of new-onset atrial fibrillation included age > 65 years, hypertension, and Pd/Pvm. A cut-off value of 870 ms/mV gave sensitivity, specificity, positive and negative predictive values of 51, 79, 30 and 87%, respectively. The Pd/Pvm was the only ECG predictor of AF with a significant multivariate hazard ratio of 2.02 (95% CI 1.18 to 3.46, p = 0.010). P-wave dispersion as measured by the Pd/Pvm was the only ECG parameter measured which independently predicted subsequent AF identification in a cohort of stroke patients. Further prospective studies in larger cohorts are needed to validate its clinical usefulness.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 53 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 53 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 7 13%
Student > Bachelor 6 11%
Student > Master 5 9%
Researcher 4 8%
Student > Doctoral Student 3 6%
Other 12 23%
Unknown 16 30%
Readers by discipline Count As %
Medicine and Dentistry 21 40%
Neuroscience 3 6%
Nursing and Health Professions 2 4%
Agricultural and Biological Sciences 1 2%
Psychology 1 2%
Other 6 11%
Unknown 19 36%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 July 2017.
All research outputs
#21,623,829
of 24,135,931 outputs
Outputs from BMC Cardiovascular Disorders
#1,459
of 1,777 outputs
Outputs of similar age
#280,659
of 319,867 outputs
Outputs of similar age from BMC Cardiovascular Disorders
#41
of 51 outputs
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