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Mendeley readers
| Title |
Transforming growth factors-β are not good biomarkers of chemopreventive efficacy in a preclinical breast cancer model system
|
|---|---|
| Published in |
Breast Cancer Research, December 2000
|
| DOI | 10.1186/bcr273 |
| Pubmed ID | |
| Authors |
JoAnne Zujewski, Anika Vaughn-Cooke, Kathleen C Flanders, Michael A Eckhaus, Ronald A Lubet, Lalage M Wakefield |
| Abstract |
Using a carcinogen-initiated rat model of mammary tumorigenesis, we tested the hypothesis that transforming growth factor (TGF)-betas are useful biomarkers of chemopreventive efficacy in the breast. The chemopreventive agents tested were tamoxifen and the retinoids 9-cis-retinoic acid (9cRA) and N-(4-hydroxyphenyl)retinamide (4-HPR), because both antiestrogens and retinoids have previously been shown to upregulate TGF-betas in vitro. Despite demonstrable chemopreventive efficacy in this model, none of these agents, alone or in combination, had any significant impact on the expression of TGF-betas in the mammary ductal epithelium or periductal stroma as determined by immunohistochemistry. These data suggest that TGF-betas are not likely to be useful biomarkers of chemopreventive efficacy in a clinical setting. |
Mendeley readers
The data shown below were compiled from readership statistics for 16 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 16 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 4 | 25% |
| Other | 3 | 19% |
| Professor > Associate Professor | 2 | 13% |
| Student > Ph. D. Student | 1 | 6% |
| Student > Bachelor | 1 | 6% |
| Other | 2 | 13% |
| Unknown | 3 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 4 | 25% |
| Biochemistry, Genetics and Molecular Biology | 2 | 13% |
| Computer Science | 2 | 13% |
| Psychology | 2 | 13% |
| Business, Management and Accounting | 1 | 6% |
| Other | 2 | 13% |
| Unknown | 3 | 19% |