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Progressive postresection program (pPRP) after pancreatic resection: study protocol for a randomized controlled trial

Overview of attention for article published in Trials, February 2016
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Title
Progressive postresection program (pPRP) after pancreatic resection: study protocol for a randomized controlled trial
Published in
Trials, February 2016
DOI 10.1186/s13063-016-1200-0
Pubmed ID
Authors

Susanne Richter, Verena Uslar, Navid Tabriz, Thomas Mueser, Dirk Weyhe

Abstract

At the time of initial diagnosis, only 15-20 % of patients with pancreatic cancer present with a resectable disease. Patients with pancreatic cancer face a poor prognosis. Progression-free survival and overall survival rates are very limited, so it is important to develop concepts to improve the quality of life for their remaining lives. The proposed trial is a randomized controlled intervention study. After pancreatic resection, the intervention group (cohort A, n = 30 patients) will take part in an intensified physiotherapy program consisting of endurance and muscle force exercises. The control group (cohort B, n = 30 patients) will take part in standard physiotherapy. Both groups will receive dietary counseling and, if necessary, substitution for endocrine/exocrine pancreatic insufficiency. Quality of life will be evaluated using the Short Form-8 Health Survey and the European Organization for Research and Treatment of Cancer QLQ-C30/QLQ-PAN26 questionnaires. The aim of this study is to investigate whether intensive physiotherapy improves the quality of life of patients after pancreatic resection. If the results for the intervention group are positive, a multicenter study should be performed with appropriate statistical power. The progressive postresection program includes a structured follow-up after pancreatic resection. In this study, all patients will undergo abdominal computed tomography for follow-up 6 and 12 months postoperatively. German Clinical Trials Register DRKS00006786 . Date of registration 1 October 2014.

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Mendeley readers

The data shown below were compiled from readership statistics for 79 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Canada 1 1%
Unknown 78 99%

Demographic breakdown

Readers by professional status Count As %
Student > Master 11 14%
Researcher 11 14%
Student > Bachelor 7 9%
Student > Ph. D. Student 7 9%
Student > Postgraduate 5 6%
Other 11 14%
Unknown 27 34%
Readers by discipline Count As %
Medicine and Dentistry 15 19%
Nursing and Health Professions 7 9%
Sports and Recreations 7 9%
Psychology 5 6%
Biochemistry, Genetics and Molecular Biology 3 4%
Other 10 13%
Unknown 32 41%