Title |
Improved multi-level protein–protein interaction prediction with semantic-based regularization
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Published in |
BMC Bioinformatics, April 2014
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DOI | 10.1186/1471-2105-15-103 |
Pubmed ID | |
Authors |
Claudio Saccà, Stefano Teso, Michelangelo Diligenti, Andrea Passerini |
Abstract |
Protein-protein interactions can be seen as a hierarchical process occurring at three related levels: proteins bind by means of specific domains, which in turn form interfaces through patches of residues. Detailed knowledge about which domains and residues are involved in a given interaction has extensive applications to biology, including better understanding of the binding process and more efficient drug/enzyme design. Alas, most current interaction prediction methods do not identify which parts of a protein actually instantiate an interaction. Furthermore, they also fail to leverage the hierarchical nature of the problem, ignoring otherwise useful information available at the lower levels; when they do, they do not generate predictions that are guaranteed to be consistent between levels. |
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Members of the public | 1 | 50% |
Mendeley readers
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Researcher | 7 | 18% |
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Professor | 4 | 10% |
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