Title |
Non-genomic transmission of longevity between generations: potential mechanisms and evidence across species
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Published in |
Epigenetics & Chromatin, July 2017
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DOI | 10.1186/s13072-017-0145-1 |
Pubmed ID | |
Authors |
Alexander M. Vaiserman, Alexander K. Koliada, Randy L. Jirtle |
Abstract |
Accumulating animal and human data indicate that environmental exposures experienced during sensitive developmental periods may strongly influence risk of adult disease. Moreover, the effects triggered by developmental environmental cues can be transgenerationally transmitted, potentially affecting offspring health outcomes. Increasing evidence suggests a central role of epigenetic mechanisms (heritable alterations in gene expression occurring without changes in underlying DNA sequence) in mediating these effects. This review summarizes the findings from animal models, including worms, insects, and rodents, and also from human studies, indicating that lifespan and longevity-associated characteristics can be transmitted across generations via non-genetic factors. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 6 | 26% |
United Kingdom | 4 | 17% |
Malaysia | 1 | 4% |
India | 1 | 4% |
Unknown | 11 | 48% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 18 | 78% |
Scientists | 4 | 17% |
Practitioners (doctors, other healthcare professionals) | 1 | 4% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 88 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 17 | 19% |
Researcher | 15 | 17% |
Student > Bachelor | 12 | 14% |
Student > Master | 8 | 9% |
Professor > Associate Professor | 6 | 7% |
Other | 14 | 16% |
Unknown | 16 | 18% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 24 | 27% |
Agricultural and Biological Sciences | 24 | 27% |
Medicine and Dentistry | 6 | 7% |
Pharmacology, Toxicology and Pharmaceutical Science | 4 | 5% |
Immunology and Microbiology | 4 | 5% |
Other | 7 | 8% |
Unknown | 19 | 22% |