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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Single low-dose rHuIL-12 safely triggers multilineage hematopoietic and immune-mediated effects
|
|---|---|
| Published in |
Experimental Hematology & Oncology, April 2014
|
| DOI | 10.1186/2162-3619-3-11 |
| Pubmed ID | |
| Authors |
Mamata S Gokhale, Vladimir Vainstein, Jamie Tom, Simmy Thomas, Chris E Lawrence, Zoya Gluzman-Poltorak, Nicholas Siebers, Lena A Basile |
| Abstract |
Recombinant human interleukin 12 (rHuIL-12) regulates hematopoiesis and cell-mediated immunity. Based on these hematopoietic and immunomodulatory activities, a recombinant human IL-12 (rHuIL-12) is now under development to address the unmet need for a medical countermeasure against the hematopoietic syndrome of the acute radiation syndrome (HSARS) that occurs in individuals exposed to lethal radiation, and also to serve as adjuvant therapy that could provide dual hematopoietic and immunotherapeutic benefits in patients with cancer receiving chemotherapy. We sought to demonstrate in healthy subjects the safety of rHuIL-12 at single, low doses that are appropriate for use as a medical countermeasure for humans exposed to lethal radiation and as an immunomodulatory anti-cancer agent. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 52 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Canada | 1 | 2% |
| Unknown | 51 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 8 | 15% |
| Student > Bachelor | 7 | 13% |
| Student > Ph. D. Student | 7 | 13% |
| Student > Doctoral Student | 4 | 8% |
| Other | 3 | 6% |
| Other | 8 | 15% |
| Unknown | 15 | 29% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 12 | 23% |
| Immunology and Microbiology | 7 | 13% |
| Agricultural and Biological Sciences | 6 | 12% |
| Biochemistry, Genetics and Molecular Biology | 4 | 8% |
| Sports and Recreations | 2 | 4% |
| Other | 2 | 4% |
| Unknown | 19 | 37% |
Attention Score in Context
This research output has an Altmetric Attention Score of 223. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 June 2022.
All research outputs
#158,089
of 24,080,653 outputs
Outputs from Experimental Hematology & Oncology
#2
of 329 outputs
Outputs of similar age
#1,313
of 231,061 outputs
Outputs of similar age from Experimental Hematology & Oncology
#1
of 5 outputs
Altmetric has tracked 24,080,653 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 329 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.9. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 231,061 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 5 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them