Title |
The interplay of DNA methylation over time with Th2 pathway genetic variants on asthma risk and temporal asthma transition
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Published in |
Clinical Epigenetics, April 2014
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DOI | 10.1186/1868-7083-6-8 |
Pubmed ID | |
Authors |
Hongmei Zhang, Xin Tong, John W Holloway, Faisal I Rezwan, Gabrielle A Lockett, Veeresh Patil, Meredith Ray, Todd M Everson, Nelís Soto-Ramírez, S Hasan Arshad, Susan Ewart, Wilfried Karmaus |
Abstract |
Genetic effects on asthma of genes in the T-helper 2 (Th2) pathway may interact with epigenetic factors including DNA methylation. We hypothesized that interactions between genetic variants and methylation in genes in this pathway (IL4, IL4R, IL13, GATA3, and STAT6) influence asthma risk, that such influences are age-dependent, and that methylation of some CpG sites changes over time in accordance with asthma transition. We tested these hypotheses in subsamples of girls from a population-based birth cohort established on the Isle of Wight, UK, in 1989. |
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