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The role of tumor-associated macrophages in tumor vascularization

Overview of attention for article published in Vascular Cell, December 2013
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Title
The role of tumor-associated macrophages in tumor vascularization
Published in
Vascular Cell, December 2013
DOI 10.1186/2045-824x-5-20
Pubmed ID
Authors

Chunqing Guo, Annicole Buranych, Devanand Sarkar, Paul B Fisher, Xiang-Yang Wang

Abstract

Tumor vascularization is a highly complex process that involves the interaction between tumors and their surrounding stroma, as well as many distinct angiogenesis-regulating factors. Tumor associated macrophages (TAMs) represent one of the most abundant cell components in the tumor environment and key contributors to cancer-related inflammation. A large body of evidence supports the notion that TAMs play a critical role in promoting the formation of an abnormal tumor vascular network and subsequent tumor progression and invasion. Clinical and experimental evidence has shown that high levels of infiltrating TAMs are associated with poor patient prognosis and tumor resistance to therapies. In addition to stimulating angiogenesis during tumor growth, TAMs enhance tumor revascularization in response to cytotoxic therapy (e.g., radiotherapy), thereby causing cancer relapse. In this review, we highlight the emerging data related to the phenotype and polarization of TAMs in the tumor microenvironment, as well as the underlying mechanisms of macrophage function in the regulation of the angiogenic switch and tumor vascularization. Additionally, we discuss the potential of targeting pro-angiogenic TAMs, or reprograming TAMs toward a tumoricidal and angiostatic phenotype, to promote normalization of the tumor vasculature to enhance the outcome of cancer therapies.

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Mendeley readers

The data shown below were compiled from readership statistics for 135 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 <1%
Mexico 1 <1%
France 1 <1%
Canada 1 <1%
Unknown 131 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 29 21%
Student > Master 27 20%
Student > Bachelor 17 13%
Researcher 15 11%
Other 7 5%
Other 22 16%
Unknown 18 13%
Readers by discipline Count As %
Agricultural and Biological Sciences 33 24%
Medicine and Dentistry 27 20%
Biochemistry, Genetics and Molecular Biology 21 16%
Immunology and Microbiology 12 9%
Pharmacology, Toxicology and Pharmaceutical Science 4 3%
Other 16 12%
Unknown 22 16%