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Tissue distribution of emulsified γ-tocotrienol and its long-term biological effects after subcutaneous administration

Overview of attention for article published in Lipids in Health and Disease, April 2014
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Title
Tissue distribution of emulsified γ-tocotrienol and its long-term biological effects after subcutaneous administration
Published in
Lipids in Health and Disease, April 2014
DOI 10.1186/1476-511x-13-66
Pubmed ID
Authors

Lili Deng, Ying Peng, Yu Wu, Meilin Yang, Yuedi Ding, Quancheng Chen, Qiang Fu

Abstract

γ-tocotrienol (GT3), an analogue of vitamin E, has gained increasing scientific interest recently as it provides significant health benefits. It has been shown that emulsified GT3, after subcutaneous administration, has long-term biological effects. However, whether the effects are due to the increase of GT3 level in the early phase following administration or the persistent functions after accumulation in tissues is unknown. This study was conducted to determine the levels of GT3 in different tissues by high performance liquid chromatography (HPLC) with a fluorescence detector after a single-dose of GT3 with polyethylene glycol (PEG-400) emulsion via subcutaneous injection. Previous studies have explored that GT3 has favorable effects on bone and can inhibit osteoclast formation. To confirm the persistent biological activity of accumulated GT3 in tissues, receptor activator of NF-κB ligand (RANKL) and osteoprotegerin (OPG) gene expressions, which have an important role in regulating osteoclast formation, were also evaluated in bone tissue on day 1, 3, 7 and 14 after a signal subcutaneous injection of GT3.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 14 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 14 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 3 21%
Professor 2 14%
Student > Doctoral Student 2 14%
Researcher 2 14%
Student > Ph. D. Student 2 14%
Other 2 14%
Unknown 1 7%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 6 43%
Agricultural and Biological Sciences 5 36%
Social Sciences 1 7%
Medicine and Dentistry 1 7%
Unknown 1 7%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 April 2014.
All research outputs
#3,060,275
of 4,507,509 outputs
Outputs from Lipids in Health and Disease
#330
of 499 outputs
Outputs of similar age
#69,251
of 101,867 outputs
Outputs of similar age from Lipids in Health and Disease
#13
of 15 outputs
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So far Altmetric has tracked 499 research outputs from this source. They receive a mean Attention Score of 3.5. This one is in the 18th percentile – i.e., 18% of its peers scored the same or lower than it.
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We're also able to compare this research output to 15 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.