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A Simplified Up-Down Method (SUDO) for Measuring Mechanical Nociception in Rodents Using von Frey Filaments

Overview of attention for article published in Molecular Pain, January 2014
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  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (84th percentile)
  • High Attention Score compared to outputs of the same age and source (87th percentile)

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335 Mendeley
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Title
A Simplified Up-Down Method (SUDO) for Measuring Mechanical Nociception in Rodents Using von Frey Filaments
Published in
Molecular Pain, January 2014
DOI 10.1186/1744-8069-10-26
Pubmed ID
Authors

Robert P Bonin, Cyril Bories, Yves De Koninck

Abstract

The measurement of mechanosensitivity is a key method for the study of pain in animal models. This is often accomplished with the use of von Frey filaments in an up-down testing paradigm. The up-down method described by Chaplan et al. (J Neurosci Methods 53:55-63, 1994) for mechanosensitivity testing in rodents remains one of the most widely used methods for measuring pain in animals. However, this method results in animals receiving a varying number of stimuli, which may lead to animals in different groups receiving different testing experiences that influences their later responses. To standardize the measurement of mechanosensitivity we developed a simplified up-down method (SUDO) for estimating paw withdrawal threshold (PWT) with von Frey filaments that uses a constant number of five stimuli per test. We further refined the PWT calculation to allow the estimation of PWT directly from the behavioral response to the fifth stimulus, omitting the need for look-up tables.

X Demographics

X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 335 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 <1%
Italy 1 <1%
Portugal 1 <1%
Spain 1 <1%
United Kingdom 1 <1%
Unknown 329 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 63 19%
Researcher 48 14%
Student > Master 43 13%
Student > Bachelor 39 12%
Student > Doctoral Student 20 6%
Other 47 14%
Unknown 75 22%
Readers by discipline Count As %
Neuroscience 92 27%
Agricultural and Biological Sciences 62 19%
Medicine and Dentistry 41 12%
Biochemistry, Genetics and Molecular Biology 21 6%
Pharmacology, Toxicology and Pharmaceutical Science 12 4%
Other 22 7%
Unknown 85 25%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 9. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 June 2022.
All research outputs
#4,311,901
of 25,371,288 outputs
Outputs from Molecular Pain
#77
of 669 outputs
Outputs of similar age
#47,610
of 319,271 outputs
Outputs of similar age from Molecular Pain
#7
of 58 outputs
Altmetric has tracked 25,371,288 research outputs across all sources so far. Compared to these this one has done well and is in the 82nd percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 669 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.1. This one has done well, scoring higher than 88% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 319,271 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 84% of its contemporaries.
We're also able to compare this research output to 58 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 87% of its contemporaries.