Title |
G-protein inwardly rectifying potassium channel 1 (GIRK 1) gene expression correlates with tumor progression in non-small cell lung cancer
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Published in |
BMC Cancer, November 2004
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DOI | 10.1186/1471-2407-4-79 |
Pubmed ID | |
Authors |
Iwao Takanami, Yoshimasa Inoue, Masatoshi Gika |
Abstract |
G-protein inwardly rectifying potassium channel 1 (GIRK1) is thought to play a role in cell proliferation in cancer, and GIRK1 gene expression level may define a more aggressive phenotype. We detected GIRK1 expression in tissue specimens from patients with non-small cell lung cancers (NSCLCs) and assessed their clinical characteristics. Using reverse transcription-polymerase chain reaction (RT-PCR) analyses, we quantified the expression of GIRK1 in 72 patients with NSCLCs to investigate the relationship between GIRK1 expression and clinicopathologic factors and prognosis. In 72 NSCLC patients, 50 (69%) samples were evaluated as having high GIRK1 gene expression, and 22 (31%) were evaluated as having low GIRK1 gene expression. GIRK1 gene expression was significantly associated with lymph node metastasis, stage (p = 0.0194 for lymph node metastasis; p = 0.0207 for stage). The overall and stage I survival rates for patients with high GIRK1 gene expressed tumors was significantly worse than for those individuals whose tumors had low GIRK1 expression (p = 0.0004 for the overall group; p = 0.0376 for stage I). These data indicate that GIRK1 may contribute to tumor progression and GIRK1 gene expression can serve as a useful prognostic marker in the overall and stage I NSCLCs. |
Mendeley readers
Geographical breakdown
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---|---|---|
United Kingdom | 2 | 17% |
Unknown | 10 | 83% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 3 | 25% |
Student > Ph. D. Student | 3 | 25% |
Professor > Associate Professor | 2 | 17% |
Student > Doctoral Student | 1 | 8% |
Other | 1 | 8% |
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Readers by discipline | Count | As % |
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Biochemistry, Genetics and Molecular Biology | 3 | 25% |
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Physics and Astronomy | 1 | 8% |