Title |
Polymorphisms in the epidermal growth factor receptor gene and the risk of primary lung cancer: a case-control study
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Published in |
BMC Cancer, October 2007
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DOI | 10.1186/1471-2407-7-199 |
Pubmed ID | |
Authors |
Jin Eun Choi, Sun Ha Park, Kyung Mee Kim, Won Kee Lee, Sin Kam, Sung Ick Cha, Chang Ho Kim, Young Mo Kang, Young-Chul Kim, Sung Beom Han, Tae Hoon Jung, Jae Yong Park |
Abstract |
Polymorphisms in Epidermal Growth Factor Receptor (EGFR) gene may influence EGFR production and/or activity, thereby modulating susceptibility to lung cancer. To test this hypothesis, we investigated the association between polymorphisms in the EGFR gene and the risk of lung cancer in a Korean population. We first examined the frequencies of 39 candidate polymorphisms in the EGFR gene in 27 healthy Korean individuals. After then, we genotyped five polymorphisms (127378C>T, 142285G>A, 162093G>A, 181946C>T and 187114T>C) that have variant allele frequencies greater than 10%, in 582 lung cancer patients and in 582 healthy controls. Of the 5 polymorphisms, the 181946C>T genotype distribution was significantly different between the cases and controls (P = 0.04). Compared with the 181946 CC + CT genotype, the 181946 TT genotype was associated with a significantly decreased risk of lung cancer (adjusted OR = 0.63, 95% CI = 0.45-0.88, P = 0.007). When the analyses were stratified by smoking status, the protective effect of the TT genotype was statistically significant in ever-smokers (adjusted OR = 0.59, 95% CI = 0.41-0.86, P = 0.007), but not in never-smokers (adjusted OR = 0.89, 95% CI = 0.45-1.75, P = 0.73; P = 0.08, test for homogeneity). Consistent with the results of the genotyping analysis, the CGGCT haplotype with the 181946C allele was associated with a significantly increased risk of lung cancer compared to the CGGTT haplotype carrying the 181946T allele (adjusted OR = 1.50, 95% CI = 1.09-2.07, P = 0.012 and Bonferroni corrected P-value = 0.048). These results suggest that the EGFR polymorphisms, particularly the 181945C>T polymorphism, could be used as markers for the genetic susceptibility to lung cancer. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 31 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Bachelor | 8 | 26% |
Researcher | 6 | 19% |
Student > Ph. D. Student | 5 | 16% |
Other | 2 | 6% |
Student > Doctoral Student | 2 | 6% |
Other | 5 | 16% |
Unknown | 3 | 10% |
Readers by discipline | Count | As % |
---|---|---|
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Medicine and Dentistry | 7 | 23% |
Biochemistry, Genetics and Molecular Biology | 4 | 13% |
Nursing and Health Professions | 4 | 13% |
Unspecified | 1 | 3% |
Other | 0 | 0% |
Unknown | 4 | 13% |