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Ghrelin accelerates synapse formation and activity development in cultured cortical networks

Overview of attention for article published in BMC Neuroscience, April 2014
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#34 of 640)
  • High Attention Score compared to outputs of the same age (87th percentile)
  • High Attention Score compared to outputs of the same age and source (92nd percentile)

Mentioned by

blogs
1 blog
twitter
1 tweeter

Citations

dimensions_citation
24 Dimensions

Readers on

mendeley
39 Mendeley
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Title
Ghrelin accelerates synapse formation and activity development in cultured cortical networks
Published in
BMC Neuroscience, April 2014
DOI 10.1186/1471-2202-15-49
Pubmed ID
Authors

Irina I Stoyanova, Joost le Feber

Abstract

While ghrelin was initially related to appetite stimulation and growth hormone secretion, it also has a neuroprotective effect in neurodegenerative diseases and regulates cognitive function. The cellular basis of those processes is related to synaptic efficacy and plasticity. Previous studies have shown that ghrelin not only stimulates synapse formation in cultured cortical neurons and hippocampal slices, but also alters some of the electrophysiological properties of neurons in the hypothalamus, amygdala and other subcortical areas. However, direct evidence for ghrelin's ability to modulate the activity in cortical neurons is not available yet. In this study, we investigated the effect of acylated ghrelin on the development of the activity level and activity patterns in cortical neurons, in relation to its effect on synaptogenesis. Additionally, we quantitatively evaluated the expression of the receptor for acylated ghrelin--growth hormone secretagogue receptor-1a (GHSR-1a) during development.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 39 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Japan 1 3%
Kazakhstan 1 3%
Canada 1 3%
Unknown 36 92%

Demographic breakdown

Readers by professional status Count As %
Researcher 9 23%
Student > Bachelor 7 18%
Student > Ph. D. Student 5 13%
Professor > Associate Professor 5 13%
Student > Master 3 8%
Other 6 15%
Unknown 4 10%
Readers by discipline Count As %
Neuroscience 9 23%
Agricultural and Biological Sciences 7 18%
Medicine and Dentistry 7 18%
Biochemistry, Genetics and Molecular Biology 3 8%
Pharmacology, Toxicology and Pharmaceutical Science 2 5%
Other 7 18%
Unknown 4 10%

Attention Score in Context

This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 April 2014.
All research outputs
#396,186
of 4,507,778 outputs
Outputs from BMC Neuroscience
#34
of 640 outputs
Outputs of similar age
#12,936
of 107,481 outputs
Outputs of similar age from BMC Neuroscience
#2
of 25 outputs
Altmetric has tracked 4,507,778 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 91st percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 640 research outputs from this source. They receive a mean Attention Score of 2.8. This one has done particularly well, scoring higher than 94% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 107,481 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 87% of its contemporaries.
We're also able to compare this research output to 25 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 92% of its contemporaries.