Title |
Effects of enamel matrix derivative on the proliferation and osteogenic differentiation of human gingival mesenchymal stem cells
|
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Published in |
Stem Cell Research & Therapy, April 2014
|
DOI | 10.1186/scrt441 |
Pubmed ID | |
Authors |
Shu-Man Wu, Hsien-Chung Chiu, Yu-Tang Chin, Heng-Yi Lin, Cheng-Yang Chiang, Hsiao-Pei Tu, Martin MJ Fu, Earl Fu |
Abstract |
Gingiva-derived mesenchymal stem cells (GMSCs) have recently been harvested and applied for rebuilding lost periodontal tissue. Enamel matrix derivative (EMD) has been used for periodontal regeneration and the formation of new cementum with inserting collagen fibers; however, alveolar bone formation is minimal. Recently, EMD has been shown to enhance the proliferation and mineralization of human bone marrow mesenchymal stem cells. Because the gingival flap is the major component to cover the surgical wound, the effects of EMD on the proliferation and mineralization of GMSCs were evaluated in the present study. |
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