Title |
Multilayered epithelium in a rat model and human Barrett's esophagus: Similar expression patterns of transcription factors and differentiation markers
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Published in |
BMC Gastroenterology, January 2008
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DOI | 10.1186/1471-230x-8-1 |
Pubmed ID | |
Authors |
Xiaoxin Chen, Rong Qin, Ba Liu, Yan Ma, Yinghao Su, Chung S Yang, Jonathan N Glickman, Robert D Odze, Nicholas J Shaheen |
Abstract |
In rats, esophagogastroduodenal anastomosis (EGDA) without concomitant chemical carcinogen treatment leads to gastroesophageal reflux disease, multilayered epithelium (MLE, a presumed precursor in intestinal metaplasia), columnar-lined esophagus, dysplasia, and esophageal adenocarcinoma. Previously we have shown that columnar-lined esophagus in EGDA rats resembled human Barrett's esophagus (BE) in its morphology, mucin features and expression of differentiation markers (Lab. Invest. 2004;84:753-765). The purpose of this study was to compare the phenotype of rat MLE with human MLE, in order to gain insight into the nature of MLE and its potential role in the development of BE. |
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