Title |
NQO1gene rs1800566 variant is not associated with risk for multiple sclerosis
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Published in |
BMC Neurology, April 2014
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DOI | 10.1186/1471-2377-14-87 |
Pubmed ID | |
Authors |
José A G Agúndez, Elena García-Martín, Carmen Martínez, Julián Benito-León, Jorge Millán-Pascual, Patricia Calleja, María Díaz-Sánchez, Diana Pisa, Laura Turpín-Fenoll, Hortensia Alonso-Navarro, Lucía Ayuso-Peralta, Dolores Torrecillas, José Francisco Plaza-Nieto, Félix Javier Jiménez-Jiménez |
Abstract |
A possible role of oxidative stress in the pathogenesis of multiple sclerosis (MS) and in experimental autoimmune encephalomyelitis has been suggested. The detoxification enzyme NAD(P)H dehydrogenase, quinone 1 (NQO1) has been found up-regulated in MS lesions. A previous report described an association between the SNP rs1800566 in the NQO1 gene and the risk for MS in the Greek population. The aim of this study was to replicate a possible influence of the. SNP rs1800566 in the NQO1 gene in the risk for MS in the Spanish Caucasian population. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Spain | 1 | 3% |
Unknown | 29 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
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Other | 4 | 13% |
Student > Ph. D. Student | 4 | 13% |
Researcher | 4 | 13% |
Student > Master | 3 | 10% |
Student > Doctoral Student | 1 | 3% |
Other | 2 | 7% |
Unknown | 12 | 40% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 6 | 20% |
Neuroscience | 4 | 13% |
Biochemistry, Genetics and Molecular Biology | 3 | 10% |
Agricultural and Biological Sciences | 3 | 10% |
Sports and Recreations | 1 | 3% |
Other | 2 | 7% |
Unknown | 11 | 37% |