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Mendeley readers
| Title |
Tryptophan 2,3-dioxygenase is a key modulator of physiological neurogenesis and anxiety-related behavior in mice
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|---|---|
| Published in |
Molecular Brain, March 2009
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| DOI | 10.1186/1756-6606-2-8 |
| Pubmed ID | |
| Authors |
Masaaki Kanai, Hiroshi Funakoshi, Hisaaki Takahashi, Tomoko Hayakawa, Shinya Mizuno, Kunio Matsumoto, Toshikazu Nakamura |
| Abstract |
Although nutrients, including amino acids and their metabolites such as serotonin (5-HT), are strong modulators of anxiety-related behavior, the metabolic pathway(s) responsible for this physiological modulation is not fully understood. Regarding tryptophan (Trp), the initial rate-limiting enzymes for the kynurenine pathway of tryptophan metabolism are tryptophan 2,3-dioxygenase (TDO) and indoleamine 2,3-dioxygenase (IDO). Here, we generated mice deficient for tdo (Tdo(-/-)). Compared with wild-type littermates, Tdo(-/-) mice showed increased plasma levels of Trp and its metabolites 5-hydroxyindoleacetic acid (5-HIAA) and kynurenine, as well as increased levels of Trp, 5-HT and 5-HIAA in the hippocampus and midbrain. These mice also showed anxiolytic modulation in the elevated plus maze and open field tests, and increased adult neurogenesis, as evidenced by double staining of BrdU and neural progenitor/neuronal markers. These findings demonstrate a direct molecular link between Trp metabolism and neurogenesis and anxiety-related behavior under physiological conditions. |
Mendeley readers
The data shown below were compiled from readership statistics for 193 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 5 | 3% |
| Japan | 2 | 1% |
| Brazil | 1 | <1% |
| Hungary | 1 | <1% |
| Belgium | 1 | <1% |
| Unknown | 183 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 38 | 20% |
| Student > Ph. D. Student | 33 | 17% |
| Student > Bachelor | 24 | 12% |
| Student > Master | 15 | 8% |
| Student > Doctoral Student | 13 | 7% |
| Other | 33 | 17% |
| Unknown | 37 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 54 | 28% |
| Biochemistry, Genetics and Molecular Biology | 24 | 12% |
| Neuroscience | 20 | 10% |
| Medicine and Dentistry | 20 | 10% |
| Chemistry | 9 | 5% |
| Other | 25 | 13% |
| Unknown | 41 | 21% |