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Evaluation of two formulations of adjuvanted RTS, S malaria vaccine in children aged 3 to 5 years living in a malaria-endemic region of Mozambique: a Phase I/IIb randomized double-blind bridging trial

Overview of attention for article published in Trials, March 2007
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Title
Evaluation of two formulations of adjuvanted RTS, S malaria vaccine in children aged 3 to 5 years living in a malaria-endemic region of Mozambique: a Phase I/IIb randomized double-blind bridging trial
Published in
Trials, March 2007
DOI 10.1186/1745-6215-8-11
Pubmed ID
Authors

Eusebio V Macete, Jahit Sacarlal, John J Aponte, Amanda Leach, Margarita M Navia, Jessica Milman, Caterina Guinovart, Inacio Mandomando, Yolanda López-Púa, Marc Lievens, Alex Owusu-Ofori, Marie-Claude Dubois, Conor P Cahill, Marguerite Koutsoukos, Marla Sillman, Ricardo Thompson, Filip Dubovsky, W Ripley Ballou, Joe Cohen, Pedro L Alonso

Abstract

Previous trials of the RTS, S malaria candidate vaccine have shown that this vaccine is safe, tolerated and immunogenic. The development plan for this vaccine aims at administering it in the first year of life through the Expanded Program on Immunization (EPI). The objective was to evaluate the safety and reactogenicity of RTS, S/AS02D (0.5 ml dose), a pediatric formulation of GlaxoSmithKline Biologicals' current malaria candidate vaccine RTS, S/AS02A (0.25 ml dose). A 0.5 ml dose of AS02D is composed of the same active ingredients in the same quantities as in a 0.25 ml dose of AS02A and has been developed to be easily introduced into routine EPI practices.

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Mendeley readers

The data shown below were compiled from readership statistics for 68 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 2 3%
Spain 1 1%
United States 1 1%
Kenya 1 1%
Unknown 63 93%

Demographic breakdown

Readers by professional status Count As %
Researcher 17 25%
Student > Ph. D. Student 11 16%
Student > Master 10 15%
Other 5 7%
Student > Doctoral Student 3 4%
Other 13 19%
Unknown 9 13%
Readers by discipline Count As %
Medicine and Dentistry 21 31%
Agricultural and Biological Sciences 16 24%
Immunology and Microbiology 7 10%
Social Sciences 3 4%
Biochemistry, Genetics and Molecular Biology 2 3%
Other 6 9%
Unknown 13 19%