Title |
Evaluation of two formulations of adjuvanted RTS, S malaria vaccine in children aged 3 to 5 years living in a malaria-endemic region of Mozambique: a Phase I/IIb randomized double-blind bridging trial
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Published in |
Trials, March 2007
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DOI | 10.1186/1745-6215-8-11 |
Pubmed ID | |
Authors |
Eusebio V Macete, Jahit Sacarlal, John J Aponte, Amanda Leach, Margarita M Navia, Jessica Milman, Caterina Guinovart, Inacio Mandomando, Yolanda López-Púa, Marc Lievens, Alex Owusu-Ofori, Marie-Claude Dubois, Conor P Cahill, Marguerite Koutsoukos, Marla Sillman, Ricardo Thompson, Filip Dubovsky, W Ripley Ballou, Joe Cohen, Pedro L Alonso |
Abstract |
Previous trials of the RTS, S malaria candidate vaccine have shown that this vaccine is safe, tolerated and immunogenic. The development plan for this vaccine aims at administering it in the first year of life through the Expanded Program on Immunization (EPI). The objective was to evaluate the safety and reactogenicity of RTS, S/AS02D (0.5 ml dose), a pediatric formulation of GlaxoSmithKline Biologicals' current malaria candidate vaccine RTS, S/AS02A (0.25 ml dose). A 0.5 ml dose of AS02D is composed of the same active ingredients in the same quantities as in a 0.25 ml dose of AS02A and has been developed to be easily introduced into routine EPI practices. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United Kingdom | 2 | 3% |
Spain | 1 | 1% |
United States | 1 | 1% |
Kenya | 1 | 1% |
Unknown | 63 | 93% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 17 | 25% |
Student > Ph. D. Student | 11 | 16% |
Student > Master | 10 | 15% |
Other | 5 | 7% |
Student > Doctoral Student | 3 | 4% |
Other | 13 | 19% |
Unknown | 9 | 13% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 21 | 31% |
Agricultural and Biological Sciences | 16 | 24% |
Immunology and Microbiology | 7 | 10% |
Social Sciences | 3 | 4% |
Biochemistry, Genetics and Molecular Biology | 2 | 3% |
Other | 6 | 9% |
Unknown | 13 | 19% |