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Severe hypoxia exerts parallel and cell-specific regulation of gene expression and alternative splicing in human mesenchymal stem cells

Overview of attention for article published in BMC Genomics, April 2014
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Title
Severe hypoxia exerts parallel and cell-specific regulation of gene expression and alternative splicing in human mesenchymal stem cells
Published in
BMC Genomics, April 2014
DOI 10.1186/1471-2164-15-303
Pubmed ID
Authors

Xinyang Hu, Rongrong Wu, Lina A Shehadeh, Qing Zhou, Cizhong Jiang, Xin Huang, Ling Zhang, Feng Gao, Xianbao Liu, Hong Yu, Keith A Webster, Jian’an Wang

Abstract

The endosteum of the bone marrow provides a specialized hypoxic niche that may serve to preserve the integrity, pluripotency, longevity and stemness of resident mesenchymal stem cells (MSCs). To explore the molecular genetic consequences of such a niche we subjected human (h) MSCs to a pO2 of 4 mmHg and analyzed global gene expression and alternative splicing (AS) by genome-exon microarray and RT-qPCR, and phenotype by western blot and immunostaining.

X Demographics

X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 65 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 3%
United Kingdom 1 2%
Unknown 62 95%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 20 31%
Researcher 11 17%
Student > Master 7 11%
Student > Bachelor 6 9%
Professor > Associate Professor 4 6%
Other 11 17%
Unknown 6 9%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 19 29%
Agricultural and Biological Sciences 15 23%
Medicine and Dentistry 10 15%
Neuroscience 4 6%
Immunology and Microbiology 2 3%
Other 4 6%
Unknown 11 17%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 April 2014.
All research outputs
#18,371,293
of 22,754,104 outputs
Outputs from BMC Genomics
#8,164
of 10,637 outputs
Outputs of similar age
#164,078
of 227,082 outputs
Outputs of similar age from BMC Genomics
#119
of 180 outputs
Altmetric has tracked 22,754,104 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 10,637 research outputs from this source. They receive a mean Attention Score of 4.7. This one is in the 12th percentile – i.e., 12% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 227,082 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 14th percentile – i.e., 14% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 180 others from the same source and published within six weeks on either side of this one. This one is in the 18th percentile – i.e., 18% of its contemporaries scored the same or lower than it.