Title |
Pancreatic insulinoma co-existing with gastric GIST in the absence of neurofibromatosis-1
|
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Published in |
World Journal of Surgical Oncology, February 2009
|
DOI | 10.1186/1477-7819-7-18 |
Pubmed ID | |
Authors |
Edward Alabraba, Simon Bramhall, Brendan O'Sullivan, Brinder Mahon, Philippe Taniere |
Abstract |
Gastrointestinal stromal tumours (GIST) frequently occur in patients with neurofibromatosis type 1 (NF-1). It has been reported that GIST may co-exist with pancreatic endocrine tumors but this has only been in association with NF-1. A 76 year old woman presented with a 12 month history of hypoglycaemia symptoms. Abdominal CT scan demonstrated a 13 mm insulinoma localized in the tail of her pancreas. She was commenced on diazoxide and later underwent surgery for enucleation of insulinoma when a small (< 1 cm) incidental tumour was discovered on her stomach wall which was identified as GIST. This is the first case report of a pancreatic insulinoma co-existing with a GIST in a patient without NF-1. In addition, we make the first report of rapidly growing cystic GIST recurrence following resection of a primary GIST tumour. |
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