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Immunohistochemical localization of glucose transporter 1 and 3 in the scrotal and abdominal testes of a dog

Overview of attention for article published in Laboratory Animal Research, October 2019
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Title
Immunohistochemical localization of glucose transporter 1 and 3 in the scrotal and abdominal testes of a dog
Published in
Laboratory Animal Research, October 2019
DOI 10.5625/lar.2017.33.2.114
Pubmed ID
Authors

Kyu Ri Hahn, Hyo Young Jung, Dae Young Yoo, Jong Whi Kim, Yang Hee Kim, Young Kwang Jo, Geon A. Kim, Jin Young Chung, Jung Hoon Choi, In Koo Hwang, Goo Jang, Yeo Sung Yoon

Abstract

Glucose is essential for testicular function; the uptake of carbohydrate-derived glucose by cells is mediated by glucose transporters (GLUTs). In the present study, we investigated the activity of GLUT1 and GLUT3, the two main isoforms of GLUTs found in testes, in the left scrotal and right abdominal testes of a German Shepherd dog. Immunohistochemical analysis showed that GLUT1 immunoreactivity was absent in the scrotal and abdominal testes. In contrast, weak to moderate GLUT3 immunoreactivity was observed in mature spermatocytes as well as spermatids in the scrotal testis. In the abdominal testis, relatively strong GLUT3 immunoreactivity was detected in Leydig cells only and was absent in mature spermatocytes and spermatids. GLUT3 immunoreactivity was significantly decreased in the tubular region of abdominal testis and significantly increased in the extra-tubular (interstitial) region of abdominal testis compared to observations in the each region of scrotal testis, respectively. These results suggest that GLUT3 is the major glucose transporter in the testes and that abdominal testes may increase the uptake of glucose into interstitial areas, leading to an increased risk of developing cancer.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 10 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 10 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 2 20%
Lecturer 1 10%
Student > Bachelor 1 10%
Student > Doctoral Student 1 10%
Professor 1 10%
Other 1 10%
Unknown 3 30%
Readers by discipline Count As %
Agricultural and Biological Sciences 4 40%
Medicine and Dentistry 2 20%
Veterinary Science and Veterinary Medicine 1 10%
Unknown 3 30%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 July 2017.
All research outputs
#22,764,772
of 25,382,440 outputs
Outputs from Laboratory Animal Research
#116
of 149 outputs
Outputs of similar age
#319,714
of 372,387 outputs
Outputs of similar age from Laboratory Animal Research
#23
of 33 outputs
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So far Altmetric has tracked 149 research outputs from this source. They receive a mean Attention Score of 4.8. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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