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Efficacy and safety of pamidronate in Modic type 1 changes: study protocol for a prospective randomized controlled clinical trial

Overview of attention for article published in Trials, April 2014
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Title
Efficacy and safety of pamidronate in Modic type 1 changes: study protocol for a prospective randomized controlled clinical trial
Published in
Trials, April 2014
DOI 10.1186/1745-6215-15-117
Pubmed ID
Authors

Stella Cecchetti, Bruno Pereira, Antoine Roche, Christophe Deschaumes, Dihya Abdi, Emmanuel Coudeyre, Jean-Jacques Dubost, Sylvain Mathieu, Sandrine Malochet-Guinamand, Anne Tournadre, Marion Couderc, Marielle Vayssade, Coline Daron, Martin Soubrier

Abstract

Erosive degenerative disc disease, also known as Modic type 1 changes, is usually characterized by low back pain with an inflammatory pain pattern, as seen in spondyloarthropathies. Intravenous pamidronate has proven to be effective in patients with ankylosing spondylitis who are refractory to nonsteroidal antiinflammatory drugs, and in painful bone diseases in general, such as Paget's disease, fibrous dysplasia or vertebral fractures. We therefore hypothesize that pamidronate would be effective in treating low back pain associated with Modic type 1 changes.

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Mendeley readers

The data shown below were compiled from readership statistics for 100 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 1%
Unknown 99 99%

Demographic breakdown

Readers by professional status Count As %
Student > Master 14 14%
Researcher 13 13%
Other 12 12%
Student > Ph. D. Student 11 11%
Student > Bachelor 7 7%
Other 18 18%
Unknown 25 25%
Readers by discipline Count As %
Medicine and Dentistry 41 41%
Nursing and Health Professions 10 10%
Agricultural and Biological Sciences 6 6%
Pharmacology, Toxicology and Pharmaceutical Science 3 3%
Sports and Recreations 2 2%
Other 8 8%
Unknown 30 30%