Title |
Efficacy and safety of pamidronate in Modic type 1 changes: study protocol for a prospective randomized controlled clinical trial
|
---|---|
Published in |
Trials, April 2014
|
DOI | 10.1186/1745-6215-15-117 |
Pubmed ID | |
Authors |
Stella Cecchetti, Bruno Pereira, Antoine Roche, Christophe Deschaumes, Dihya Abdi, Emmanuel Coudeyre, Jean-Jacques Dubost, Sylvain Mathieu, Sandrine Malochet-Guinamand, Anne Tournadre, Marion Couderc, Marielle Vayssade, Coline Daron, Martin Soubrier |
Abstract |
Erosive degenerative disc disease, also known as Modic type 1 changes, is usually characterized by low back pain with an inflammatory pain pattern, as seen in spondyloarthropathies. Intravenous pamidronate has proven to be effective in patients with ankylosing spondylitis who are refractory to nonsteroidal antiinflammatory drugs, and in painful bone diseases in general, such as Paget's disease, fibrous dysplasia or vertebral fractures. We therefore hypothesize that pamidronate would be effective in treating low back pain associated with Modic type 1 changes. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 1% |
Unknown | 99 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 14 | 14% |
Researcher | 13 | 13% |
Other | 12 | 12% |
Student > Ph. D. Student | 11 | 11% |
Student > Bachelor | 7 | 7% |
Other | 18 | 18% |
Unknown | 25 | 25% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 41 | 41% |
Nursing and Health Professions | 10 | 10% |
Agricultural and Biological Sciences | 6 | 6% |
Pharmacology, Toxicology and Pharmaceutical Science | 3 | 3% |
Sports and Recreations | 2 | 2% |
Other | 8 | 8% |
Unknown | 30 | 30% |