Title |
Abnormal expression of A20 and its regulated genes in peripheral blood from patients with lymphomas
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Published in |
Cancer Cell International, April 2014
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DOI | 10.1186/1475-2867-14-36 |
Pubmed ID | |
Authors |
Xu Wang, Yan Xu, Lichan Liang, Yi Xu, Chunyan Wang, Liang Wang, Shaohua Chen, Lijian Yang, Xiuli Wu, Bo Li, Gengxin Luo, Huo Tan, Wenyu Li, Yangqiu Li |
Abstract |
Cell-mediated immunity is often suppressed in patients with hematological malignancies. Recently, we found that low T cell receptor (TCR)-CD3 signaling was related to abnormal expression of the negative regulator of nuclear factor kappa B (NF-κB) A20 in acute myeloid leukemia. To investigate the characteristics of T cell immunodeficiency in lymphomas, we analyzed the expression features of A20 and its upstream regulating factor mucosa-associated lymphoid tissue lymphoma translocation gene 1 (MALT1) and genes downstream of NF-κB in patients with different lymphoma subtypes, including T cell non-Hodgkin lymphoma (T-NHL), B cell non-Hodgkin lymphoma (B-NHL) and NK/T cell lymphoma (NK/T-CL). |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 2 | 50% |
Unknown | 2 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 50% |
Science communicators (journalists, bloggers, editors) | 1 | 25% |
Practitioners (doctors, other healthcare professionals) | 1 | 25% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United States | 1 | 8% |
Unknown | 11 | 92% |
Demographic breakdown
Readers by professional status | Count | As % |
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Other | 3 | 25% |
Student > Ph. D. Student | 3 | 25% |
Student > Bachelor | 1 | 8% |
Researcher | 1 | 8% |
Student > Postgraduate | 1 | 8% |
Other | 0 | 0% |
Unknown | 3 | 25% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 2 | 17% |
Medicine and Dentistry | 2 | 17% |
Nursing and Health Professions | 2 | 17% |
Biochemistry, Genetics and Molecular Biology | 1 | 8% |
Immunology and Microbiology | 1 | 8% |
Other | 1 | 8% |
Unknown | 3 | 25% |