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Radiation-induced meningiomas in multiple regions, showing rapid recurrence and a high MIB 1 labeling index: a case report and review of the literature

Overview of attention for article published in World Journal of Surgical Oncology, April 2014
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Title
Radiation-induced meningiomas in multiple regions, showing rapid recurrence and a high MIB 1 labeling index: a case report and review of the literature
Published in
World Journal of Surgical Oncology, April 2014
DOI 10.1186/1477-7819-12-123
Pubmed ID
Authors

Yoshiaki Goto, So Yamada, Shoko M Yamada, Hiroshi Nakaguchi, Katsumi Hoya, Mineko Murakami, Kazuto Yamazaki, Yasuo Ishida, Akira Matsuno

Abstract

Combined chemotherapy and prophylactic cranial irradiation has improved the prognosis of children with acute leukemia. However cranial irradiation carries a latent risk of the induction of secondary intracranial tumors. We encountered a patient who developed multiple intracranial radiation-induced meningiomas (RIMs) 25 years after prophylactic cranial irradiation for the treatment of acute leukemia in childhood. The patient had 3 intracranial lesions, 1 of which showed rapid growth within 6 months; another of the tumors also enlarged within a short period. All of the tumors were surgically treated, and immunohistochemistry indicated a high MIB-1 labeling index in each of the multiple lesions. In the literature, the MIB-1 labeling indices of 27 tumors from 21 patients were examined. Among them, 12 recurrent tumors showed higher MIB-1 labeling indices compared to the MIB-1 labeling indices of the non-recurrent tumors. Overall, 11 of the patients with RIM had multiple lesions and 8 cases developed recurrence (72.7%). RIM cases with multiple lesions had higher MIB-1 labeling indices compared to the MIB-1 labeling indices of cases with single lesions. Collectively, these data showed that the MIB-1 labeling index is as important for predicting RIM recurrences, as it is for predicting sporadic meningioma (SM) recurrences. RIMs should be treated more aggressively than SMs because of their greater malignant potential.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 31 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Nigeria 1 3%
Unknown 30 97%

Demographic breakdown

Readers by professional status Count As %
Student > Master 5 16%
Student > Bachelor 4 13%
Researcher 4 13%
Student > Ph. D. Student 4 13%
Student > Postgraduate 2 6%
Other 5 16%
Unknown 7 23%
Readers by discipline Count As %
Medicine and Dentistry 18 58%
Neuroscience 2 6%
Nursing and Health Professions 1 3%
Biochemistry, Genetics and Molecular Biology 1 3%
Chemistry 1 3%
Other 0 0%
Unknown 8 26%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 April 2014.
All research outputs
#20,657,128
of 25,374,917 outputs
Outputs from World Journal of Surgical Oncology
#1,099
of 2,145 outputs
Outputs of similar age
#177,918
of 241,649 outputs
Outputs of similar age from World Journal of Surgical Oncology
#39
of 73 outputs
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