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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Stable 293 T and CHO cell lines expressing cleaved, stable HIV-1 envelope glycoprotein trimers for structural and vaccine studies
|
|---|---|
| Published in |
Retrovirology, April 2014
|
| DOI | 10.1186/1742-4690-11-33 |
| Pubmed ID | |
| Authors |
Nancy PY Chung, Katie Matthews, Helen J Kim, Thomas J Ketas, Michael Golabek, Kevin de los Reyes, Jacob Korzun, Anila Yasmeen, Rogier W Sanders, Per Johan Klasse, Ian A Wilson, Andrew B Ward, Andre J Marozsan, John P Moore, Albert Cupo |
| Abstract |
Recombinant soluble, cleaved HIV-1 envelope glycoprotein SOSIP.664 gp140 trimers based on the subtype A BG505 sequence are being studied structurally and tested as immunogens in animals. For these trimers to become a vaccine candidate for human trials, they would need to be made in appropriate amounts at an acceptable quality. Accomplishing such tasks by transient transfection is likely to be challenging. The traditional way to express recombinant proteins in large amounts is via a permanent cell line, usually of mammalian origin. Making cell lines that produce BG505 SOSIP.664 trimers requires the co-expression of the Furin protease to ensure that the cleavage site between the gp120 and gp41 subunits is fully utilized. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 58 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 2% |
| Puerto Rico | 1 | 2% |
| South Africa | 1 | 2% |
| Unknown | 55 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 12 | 21% |
| Student > Ph. D. Student | 10 | 17% |
| Student > Bachelor | 8 | 14% |
| Student > Master | 8 | 14% |
| Student > Doctoral Student | 4 | 7% |
| Other | 8 | 14% |
| Unknown | 8 | 14% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 15 | 26% |
| Agricultural and Biological Sciences | 15 | 26% |
| Immunology and Microbiology | 5 | 9% |
| Chemistry | 3 | 5% |
| Medicine and Dentistry | 3 | 5% |
| Other | 8 | 14% |
| Unknown | 9 | 16% |
Attention Score in Context
This research output has an Altmetric Attention Score of 11. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 September 2015.
All research outputs
#3,274,898
of 25,374,917 outputs
Outputs from Retrovirology
#135
of 1,273 outputs
Outputs of similar age
#31,590
of 241,810 outputs
Outputs of similar age from Retrovirology
#2
of 23 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. Compared to these this one has done well and is in the 86th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,273 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.7. This one has done well, scoring higher than 89% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 241,810 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 86% of its contemporaries.
We're also able to compare this research output to 23 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 91% of its contemporaries.