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Infliximab’s influence on anastomotic strength and degree of inflammation in intestinal surgery in a rabbit model

Overview of attention for article published in BMC Surgery, April 2014
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Title
Infliximab’s influence on anastomotic strength and degree of inflammation in intestinal surgery in a rabbit model
Published in
BMC Surgery, April 2014
DOI 10.1186/1471-2482-14-23
Pubmed ID
Authors

Erik Frostberg, Petter Ström, Oke Gerke, Niels Qvist

Abstract

Infliximab, a TNF-α inhibitor, is a potent anti-inflammatory drug in the treatment of inflammatory bowel diseases. Recent studies have investigated the effect of infliximab treatment on postoperative complications such as anastomotic leakage, however, with conflicting results and conclusions. The purpose of this study was to investigate whether a single dose infliximab has an adverse effect on the anastomotic healing process, observed as reduced anastomotic breaking strength and histopathologically verified lower grade of inflammatory response, in the small intestine of a rabbit.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 14 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 14 100%

Demographic breakdown

Readers by professional status Count As %
Other 2 14%
Student > Ph. D. Student 2 14%
Student > Doctoral Student 1 7%
Student > Bachelor 1 7%
Lecturer 1 7%
Other 4 29%
Unknown 3 21%
Readers by discipline Count As %
Medicine and Dentistry 7 50%
Biochemistry, Genetics and Molecular Biology 1 7%
Pharmacology, Toxicology and Pharmaceutical Science 1 7%
Social Sciences 1 7%
Computer Science 1 7%
Other 0 0%
Unknown 3 21%