Title |
Effect of ret/PTC 1 rearrangement on transcription and post-transcriptional regulation in a papillary thyroid carcinoma model
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Published in |
Molecular Cancer, December 2006
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DOI | 10.1186/1476-4598-5-70 |
Pubmed ID | |
Authors |
Susanne Cahill, Paul Smyth, Stephen P Finn, Karen Denning, Richard Flavin, Esther M O'Regan, Jinghuan Li, Astrid Potratz, Simone M Guenther, Richard Henfrey, John J O'Leary, Orla Sheils |
Abstract |
microRNAs (miRNAs) are a group of non-coding single stranded RNAs measuring approximately 22 nt in length that have been found to control cell growth, differentiation and apoptosis. miRNAs negatively regulate their target genes and recently have been implicated in tumourigenesis. Furthermore, miRNA expression profiling correlates with various cancers, with these genes thought to act as both tumour suppressors and oncogenes. ret/PTC 1 is an oncogene with constitutive kinase activity implicated in the development of papillary thyroid carcinoma (PTC). This rearrangement leads to aberrant MAPK activation that is implicated in PTC tumourigenesis. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United States | 2 | 4% |
Germany | 1 | 2% |
Unknown | 53 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 21 | 38% |
Student > Ph. D. Student | 6 | 11% |
Professor | 5 | 9% |
Other | 4 | 7% |
Professor > Associate Professor | 4 | 7% |
Other | 9 | 16% |
Unknown | 7 | 13% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 22 | 39% |
Biochemistry, Genetics and Molecular Biology | 13 | 23% |
Medicine and Dentistry | 9 | 16% |
Computer Science | 2 | 4% |
Neuroscience | 1 | 2% |
Other | 0 | 0% |
Unknown | 9 | 16% |