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Transcriptional and functional complexity of Shank3 provides a molecular framework to understand the phenotypic heterogeneity of SHANK3 causing autism and Shank3 mutant mice

Overview of attention for article published in Molecular Autism, April 2014
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (85th percentile)
  • Above-average Attention Score compared to outputs of the same age and source (60th percentile)

Mentioned by

blogs
1 blog
twitter
3 X users

Citations

dimensions_citation
130 Dimensions

Readers on

mendeley
218 Mendeley
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Title
Transcriptional and functional complexity of Shank3 provides a molecular framework to understand the phenotypic heterogeneity of SHANK3 causing autism and Shank3 mutant mice
Published in
Molecular Autism, April 2014
DOI 10.1186/2040-2392-5-30
Pubmed ID
Authors

Xiaoming Wang, Qiong Xu, Alexandra L Bey, Yoonji Lee, Yong-hui Jiang

Abstract

Considerable clinical heterogeneity has been well documented amongst individuals with autism spectrum disorders (ASD). However, little is known about the biological mechanisms underlying phenotypic diversity. Genetic studies have established a strong causal relationship between ASD and molecular defects in the SHANK3 gene. Individuals with various defects of SHANK3 display considerable clinical heterogeneity. Different lines of Shank3 mutant mice with deletions of different portions of coding exons have been reported recently. Variable synaptic and behavioral phenotypes have been reported in these mice, which makes the interpretations for these data complicated without the full knowledge of the complexity of the Shank3 transcript structure.

X Demographics

X Demographics

The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 218 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Spain 1 <1%
Colombia 1 <1%
France 1 <1%
Unknown 215 99%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 43 20%
Researcher 39 18%
Student > Bachelor 31 14%
Student > Master 23 11%
Student > Doctoral Student 16 7%
Other 24 11%
Unknown 42 19%
Readers by discipline Count As %
Neuroscience 54 25%
Agricultural and Biological Sciences 52 24%
Biochemistry, Genetics and Molecular Biology 24 11%
Medicine and Dentistry 16 7%
Psychology 8 4%
Other 16 7%
Unknown 48 22%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 May 2018.
All research outputs
#3,249,701
of 22,754,104 outputs
Outputs from Molecular Autism
#309
of 664 outputs
Outputs of similar age
#33,777
of 226,861 outputs
Outputs of similar age from Molecular Autism
#2
of 5 outputs
Altmetric has tracked 22,754,104 research outputs across all sources so far. Compared to these this one has done well and is in the 85th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 664 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 28.4. This one has gotten more attention than average, scoring higher than 53% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 226,861 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 85% of its contemporaries.
We're also able to compare this research output to 5 others from the same source and published within six weeks on either side of this one. This one has scored higher than 3 of them.