Title |
Screening of Lactobacillus spp. for the prevention of Pseudomonas aeruginosa pulmonary infections
|
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Published in |
BMC Microbiology, April 2014
|
DOI | 10.1186/1471-2180-14-107 |
Pubmed ID | |
Authors |
Youenn Alexandre, Rozenn Le Berre, Georges Barbier, Gwenaelle Le Blay |
Abstract |
Pseudomonas aeruginosa is an opportunistic pathogen that significantly increases morbidity and mortality in nosocomial infections and cystic fibrosis patients. Its pathogenicity especially relies on the production of virulence factors or resistances to many antibiotics. Since multiplication of antibiotic resistance can lead to therapeutic impasses, it becomes necessary to develop new tools for fighting P. aeruginosa infections. The use of probiotics is one of the ways currently being explored. Probiotics are microorganisms that exert a positive effect on the host's health and some of them are known to possess antibacterial activities. Since most of their effects have been shown in the digestive tract, experimental data compatible with the respiratory environment are strongly needed. The main goal of this study was then to test the capacity of lactobacilli to inhibit major virulence factors (elastolytic activity and biofilm formation) associated with P. aeruginosa pathogenicity. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 95 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 12 | 13% |
Student > Bachelor | 12 | 13% |
Student > Master | 11 | 12% |
Researcher | 7 | 7% |
Student > Doctoral Student | 6 | 6% |
Other | 16 | 17% |
Unknown | 31 | 33% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 22 | 23% |
Medicine and Dentistry | 13 | 14% |
Immunology and Microbiology | 8 | 8% |
Biochemistry, Genetics and Molecular Biology | 7 | 7% |
Pharmacology, Toxicology and Pharmaceutical Science | 3 | 3% |
Other | 9 | 9% |
Unknown | 33 | 35% |