Title |
Novel transcripts from a distinct promoter that encode the full-length AKT1 in human breast cancer cells
|
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Published in |
BMC Cancer, March 2014
|
DOI | 10.1186/1471-2407-14-195 |
Pubmed ID | |
Authors |
Jeffrey W Schmidt, Barbara L Wehde, Kazuhito Sakamoto, Aleata A Triplett, William W West, Kay-Uwe Wagner |
Abstract |
The serine-threonine kinase AKT1 plays essential roles during normal mammary gland development as well as the initiation and progression of breast cancer. AKT1 is generally considered a ubiquitously expressed gene, and its persistent activation is transcriptionally controlled by regulatory elements characteristic of housekeeping gene promoters. We recently identified a novel Akt1 transcript in mice (Akt1m), which is induced by growth factors and their signal transducers of transcription from a previously unknown promoter. The purpose of this study was to examine whether normal and neoplastic human breast epithelial cells express an orthologous AKT1m transcript and whether its expression is deregulated in cancer cells. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
India | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 11 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Doctoral Student | 3 | 27% |
Student > Bachelor | 2 | 18% |
Student > Master | 1 | 9% |
Professor | 1 | 9% |
Student > Ph. D. Student | 1 | 9% |
Other | 2 | 18% |
Unknown | 1 | 9% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 4 | 36% |
Agricultural and Biological Sciences | 3 | 27% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 18% |
Medicine and Dentistry | 1 | 9% |
Unknown | 1 | 9% |