Title |
Study protocol: Imaging brain development in the Childhood to Adolescence Transition Study (iCATS)
|
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Published in |
BMC Pediatrics, April 2014
|
DOI | 10.1186/1471-2431-14-115 |
Pubmed ID | |
Authors |
Julian G Simmons, Sarah L Whittle, George C Patton, Paul Dudgeon, Craig Olsson, Michelle L Byrne, Lisa K Mundy, Marc L Seal, Nicholas B Allen |
Abstract |
Puberty is a critical developmental phase in physical, reproductive and socio-emotional maturation that is associated with the period of peak onset for psychopathology. Puberty also drives significant changes in brain development and function. Research to date has focused on gonadarche, driven by the hypothalamic-pituitary-gonadal axis, and yet increasing evidence suggests that the earlier pubertal stage of adrenarche, driven by the hypothalamic-pituitary-adrenal axis, may play a critical role in both brain development and increased risk for disorder. We have established a unique cohort of children who differ in their exposure to adrenarcheal hormones. This presents a unique opportunity to examine the influence of adrenarcheal timing on brain structural and functional development, and subsequent health outcomes. The primary objective of the study is to explore the hypothesis that patterns of structural and functional brain development will mediate the relationship between adrenarcheal timing and indices of affect, self-regulation, and mental health symptoms collected across time (and therefore years of development). |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 3 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Scientists | 1 | 33% |
Members of the public | 1 | 33% |
Practitioners (doctors, other healthcare professionals) | 1 | 33% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 131 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 30 | 23% |
Student > Master | 15 | 11% |
Researcher | 14 | 11% |
Professor | 10 | 8% |
Student > Bachelor | 10 | 8% |
Other | 20 | 15% |
Unknown | 32 | 24% |
Readers by discipline | Count | As % |
---|---|---|
Psychology | 45 | 34% |
Medicine and Dentistry | 15 | 11% |
Neuroscience | 12 | 9% |
Social Sciences | 9 | 7% |
Nursing and Health Professions | 2 | 2% |
Other | 6 | 5% |
Unknown | 42 | 32% |