Title |
Systematic analysis of 18F-FDG PET and metabolism, proliferation and hypoxia markers for classification of head and neck tumors
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Published in |
BMC Cancer, February 2014
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DOI | 10.1186/1471-2407-14-130 |
Pubmed ID | |
Authors |
Bianca AW Hoeben, Maud HW Starmans, Ralph TH Leijenaar, Ludwig J Dubois, Albert J van der Kogel, Johannes HAM Kaanders, Paul C Boutros, Philippe Lambin, Johan Bussink |
Abstract |
Quantification of molecular cell processes is important for prognostication and treatment individualization of head and neck cancer (HNC). However, individual tumor comparison can show discord in upregulation similarities when analyzing multiple biological mechanisms. Elaborate tumor characterization, integrating multiple pathways reflecting intrinsic and microenvironmental properties, may be beneficial to group most uniform tumors for treatment modification schemes. The goal of this study was to systematically analyze if immunohistochemical (IHC) assessment of molecular markers, involved in treatment resistance, and 18F-FDG PET parameters could accurately distinguish separate HNC tumors. |
X Demographics
Geographical breakdown
Country | Count | As % |
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India | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Spain | 1 | 1% |
Denmark | 1 | 1% |
Germany | 1 | 1% |
Unknown | 65 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 12 | 18% |
Student > Ph. D. Student | 11 | 16% |
Student > Bachelor | 8 | 12% |
Other | 7 | 10% |
Student > Master | 6 | 9% |
Other | 12 | 18% |
Unknown | 12 | 18% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 28 | 41% |
Agricultural and Biological Sciences | 5 | 7% |
Biochemistry, Genetics and Molecular Biology | 4 | 6% |
Engineering | 4 | 6% |
Computer Science | 4 | 6% |
Other | 9 | 13% |
Unknown | 14 | 21% |