Title |
QGRS-Conserve: a computational method for discovering evolutionarily conserved G-quadruplex motifs
|
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Published in |
Human Genomics, May 2014
|
DOI | 10.1186/1479-7364-8-8 |
Pubmed ID | |
Authors |
Scott Frees, Camille Menendez, Matt Crum, Paramjeet S Bagga |
Abstract |
Nucleic acids containing guanine tracts can form quadruplex structures via non-Watson-Crick base pairing. Formation of G-quadruplexes is associated with the regulation of important biological functions such as transcription, genetic instability, DNA repair, DNA replication, epigenetic mechanisms, regulation of translation, and alternative splicing. G-quadruplexes play important roles in human diseases and are being considered as targets for a variety of therapies. Identification of functional G-quadruplexes and the study of their overall distribution in genomes and transcriptomes is an important pursuit. Traditional computational methods map sequence motifs capable of forming G-quadruplexes but have difficulty in distinguishing motifs that occur by chance from ones which fold into G-quadruplexes. |
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