Title |
Diversity of greek meningococcal serogroup B isolates and estimated coverage of the 4CMenB meningococcal vaccine
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Published in |
BMC Microbiology, April 2014
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DOI | 10.1186/1471-2180-14-111 |
Pubmed ID | |
Authors |
Georgina Tzanakaki, Eva Hong, Konstatinos Kesanopoulos, Athanasia Xirogianni, Stefania Bambini, Luca Orlandi, Maurizio Comanducci, Alessandro Muzzi, Muhamed-Kheir Taha |
Abstract |
Serogroup B meningococcal (MenB) isolates currently account for approximately 90% of invasive meningococcal disease (IMD) in Greece with ST-162 clonal complex predominating. The potential of a multicomponent meningococcal B vaccine (4CMenB) recently licensed in Europe was investigated in order to find whether the aforementioned vaccine will cover the MenB strains circulating in Greece. A panel of 148 serogroup B invasive meningococcal strains was characterized by multilocus sequence typing (MLST) and PorA subtyping. Vaccine components were typed by sequencing for factor H-binding protein (fHbp), Neisserial Heparin Binding Antigen (NHBA) and Neisseria adhesin A (NadA). Their expression was explored by Meningococcal Antigen Typing System (MATS). |
X Demographics
Geographical breakdown
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Venezuela, Bolivarian Republic of | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Scientists | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Netherlands | 1 | 4% |
Unknown | 25 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 6 | 23% |
Student > Ph. D. Student | 3 | 12% |
Student > Master | 3 | 12% |
Student > Postgraduate | 2 | 8% |
Professor > Associate Professor | 2 | 8% |
Other | 5 | 19% |
Unknown | 5 | 19% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 6 | 23% |
Immunology and Microbiology | 5 | 19% |
Medicine and Dentistry | 5 | 19% |
Unspecified | 1 | 4% |
Nursing and Health Professions | 1 | 4% |
Other | 3 | 12% |
Unknown | 5 | 19% |