Title |
Nano-based delivery of RNAi in cancer therapy
|
---|---|
Published in |
Molecular Cancer, July 2017
|
DOI | 10.1186/s12943-017-0683-y |
Pubmed ID | |
Authors |
Yong Xin, Min Huang, Wen Wen Guo, Qian Huang, Long zhen Zhang, Guan Jiang |
Abstract |
RNA interference (RNAi), a newly developed method in which RNA molecules inhibit gene expression, has recently received considerable research attention. In the development of RNAi-based therapies, nanoparticles, which have distinctive size effects along with facile modification strategies and are capable of mediating effective RNAi with targeting potential, are attracting extensive interest. This review presents an overview of the mechanisms of RNAi molecules in gene therapy and the different nanoparticles used to deliver RNAi molecules; briefly describes the current uses of RNAi in cancer therapy along with the nano-based delivery of RNA molecules in previous studies; and highlights some other carriers that have been applied in clinical settings. Finally, we discuss the nano-based delivery of RNAi therapeutics in preclinical development, including the current status and limitations of anti-cancer treatment. With the growing number of RNAi therapeutics entering the clinical phase, various nanocarriers are expected to play important roles in the delivery of RNAi molecules for cancer therapeutics. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
China | 1 | 25% |
France | 1 | 25% |
United States | 1 | 25% |
Unknown | 1 | 25% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 3 | 75% |
Science communicators (journalists, bloggers, editors) | 1 | 25% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 238 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 39 | 16% |
Student > Ph. D. Student | 37 | 16% |
Student > Bachelor | 37 | 16% |
Researcher | 13 | 5% |
Student > Postgraduate | 10 | 4% |
Other | 26 | 11% |
Unknown | 76 | 32% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 59 | 25% |
Pharmacology, Toxicology and Pharmaceutical Science | 30 | 13% |
Agricultural and Biological Sciences | 13 | 5% |
Medicine and Dentistry | 12 | 5% |
Chemistry | 9 | 4% |
Other | 32 | 13% |
Unknown | 83 | 35% |