Title |
PapMV nanoparticles improve mucosal immune responses to the trivalent inactivated flu vaccine
|
---|---|
Published in |
Journal of Nanobiotechnology, May 2014
|
DOI | 10.1186/1477-3155-12-19 |
Pubmed ID | |
Authors |
Gervais Rioux, Claudia Mathieu, Alexis Russell, Marilène Bolduc, Marie-Eve Laliberté-Gagné, Pierre Savard, Denis Leclerc |
Abstract |
Trivalent inactivated flu vaccines (TIV) are currently the best means to prevent influenza infections. However, the protection provided by TIV is partial (about 50%) and it is needed to improve the efficacy of protection. Since the respiratory tract is the main site of influenza replications, a vaccine that triggers mucosal immunity in this region can potentially improve protection against this disease. Recently, PapMV nanoparticles used as an adjuvant in a formulation with TIV administered by the subcutaneous route have shown improving the immune response directed to the TIV and protection against an influenza challenge. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Canada | 2 | 5% |
Unknown | 35 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 9 | 24% |
Student > Master | 8 | 22% |
Student > Ph. D. Student | 7 | 19% |
Student > Bachelor | 3 | 8% |
Student > Doctoral Student | 2 | 5% |
Other | 2 | 5% |
Unknown | 6 | 16% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 9 | 24% |
Biochemistry, Genetics and Molecular Biology | 5 | 14% |
Pharmacology, Toxicology and Pharmaceutical Science | 4 | 11% |
Medicine and Dentistry | 4 | 11% |
Immunology and Microbiology | 4 | 11% |
Other | 2 | 5% |
Unknown | 9 | 24% |