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X Demographics
Mendeley readers
Attention Score in Context
| Title |
The pivotal role of pyruvate dehydrogenase kinases in metabolic flexibility
|
|---|---|
| Published in |
Nutrition & Metabolism, February 2014
|
| DOI | 10.1186/1743-7075-11-10 |
| Pubmed ID | |
| Authors |
Shuai Zhang, Matthew W Hulver, Ryan P McMillan, Mark A Cline, Elizabeth R Gilbert |
| Abstract |
Metabolic flexibility is the capacity of a system to adjust fuel (primarily glucose and fatty acids) oxidation based on nutrient availability. The ability to alter substrate oxidation in response to nutritional state depends on the genetically influenced balance between oxidation and storage capacities. Competition between fatty acids and glucose for oxidation occurs at the level of the pyruvate dehydrogenase complex (PDC). The PDC is normally active in most tissues in the fed state, and suppressing PDC activity by pyruvate dehydrogenase (PDH) kinase (PDK) is crucial to maintain energy homeostasis under some extreme nutritional conditions in mammals. Conversely, inappropriate suppression of PDC activity might promote the development of metabolic diseases. This review summarizes PDKs' pivotal role in control of metabolic flexibility under various nutrient conditions and in different tissues, with emphasis on the best characterized PDK4. Understanding the regulation of PDC and PDKs and their roles in energy homeostasis could be beneficial to alleviate metabolic inflexibility and to provide possible therapies for metabolic diseases, including type 2 diabetes (T2D). |
X Demographics
The data shown below were collected from the profiles of 11 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 27% |
| United Kingdom | 1 | 9% |
| Spain | 1 | 9% |
| Unknown | 6 | 55% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 8 | 73% |
| Scientists | 2 | 18% |
| Practitioners (doctors, other healthcare professionals) | 1 | 9% |
Mendeley readers
The data shown below were compiled from readership statistics for 487 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 4 | <1% |
| Switzerland | 1 | <1% |
| France | 1 | <1% |
| India | 1 | <1% |
| Portugal | 1 | <1% |
| Czechia | 1 | <1% |
| Canada | 1 | <1% |
| Spain | 1 | <1% |
| United States | 1 | <1% |
| Other | 0 | 0% |
| Unknown | 475 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 97 | 20% |
| Researcher | 74 | 15% |
| Student > Master | 66 | 14% |
| Student > Bachelor | 61 | 13% |
| Student > Doctoral Student | 23 | 5% |
| Other | 74 | 15% |
| Unknown | 92 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 120 | 25% |
| Agricultural and Biological Sciences | 102 | 21% |
| Medicine and Dentistry | 61 | 13% |
| Pharmacology, Toxicology and Pharmaceutical Science | 16 | 3% |
| Sports and Recreations | 14 | 3% |
| Other | 61 | 13% |
| Unknown | 113 | 23% |
Attention Score in Context
This research output has an Altmetric Attention Score of 20. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 August 2023.
All research outputs
#1,854,106
of 25,483,400 outputs
Outputs from Nutrition & Metabolism
#227
of 1,015 outputs
Outputs of similar age
#21,494
of 329,802 outputs
Outputs of similar age from Nutrition & Metabolism
#2
of 11 outputs
Altmetric has tracked 25,483,400 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 92nd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,015 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 28.8. This one has done well, scoring higher than 77% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 329,802 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 93% of its contemporaries.
We're also able to compare this research output to 11 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 90% of its contemporaries.