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Neuroinflammation and related neuropathologies in APPSL mice: further value of this in vivomodel of Alzheimer’s disease

Overview of attention for article published in Journal of Neuroinflammation, May 2014
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Title
Neuroinflammation and related neuropathologies in APPSL mice: further value of this in vivomodel of Alzheimer’s disease
Published in
Journal of Neuroinflammation, May 2014
DOI 10.1186/1742-2094-11-84
Pubmed ID
Authors

Tina Löffler, Stefanie Flunkert, Daniel Havas, Cornelia Schweinzer, Marni Uger, Manfred Windisch, Ernst Steyrer, Birgit Hutter-Paier

Abstract

Beyond cognitive decline, Alzheimer's disease (AD) is characterized by numerous neuropathological changes in the brain. Although animal models generally do not fully reflect the broad spectrum of disease-specific alterations, the APPSL mouse model is well known to display early plaque formation and to exhibit spatial learning and memory deficits. However, important neuropathological features, such as neuroinflammation and lipid peroxidation, and their progression over age, have not yet been described in this AD mouse model.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 40 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 40 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 10 25%
Researcher 9 23%
Student > Ph. D. Student 6 15%
Student > Bachelor 2 5%
Student > Postgraduate 2 5%
Other 5 13%
Unknown 6 15%
Readers by discipline Count As %
Neuroscience 10 25%
Agricultural and Biological Sciences 7 18%
Medicine and Dentistry 6 15%
Biochemistry, Genetics and Molecular Biology 4 10%
Psychology 3 8%
Other 3 8%
Unknown 7 18%