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FGF-2 released from degenerating neurons exerts microglial-induced neuroprotection via FGFR3-ERK signaling pathway

Overview of attention for article published in Journal of Neuroinflammation, April 2014
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Title
FGF-2 released from degenerating neurons exerts microglial-induced neuroprotection via FGFR3-ERK signaling pathway
Published in
Journal of Neuroinflammation, April 2014
DOI 10.1186/1742-2094-11-76
Pubmed ID
Authors

Mariko Noda, Kento Takii, Bijay Parajuli, Jun Kawanokuchi, Yoshifumi Sonobe, Hideyuki Takeuchi, Tetsuya Mizuno, Akio Suzumura

Abstract

The accumulation of activated microglia is a hallmark of various neurodegenerative diseases. Microglia may have both protective and toxic effects on neurons through the production of various soluble factors, such as chemokines. Indeed, various chemokines mediate the rapid and accurate migration of microglia to lesions. In the zebra fish, another well-known cellular migrating factor is fibroblast growth factor-2 (FGF-2). Although FGF-2 does exist in the mammalian central nervous system (CNS), it is unclear whether FGF-2 influences microglial function.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 62 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Germany 1 2%
Unknown 61 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 15 24%
Researcher 13 21%
Student > Master 7 11%
Student > Doctoral Student 4 6%
Student > Bachelor 4 6%
Other 5 8%
Unknown 14 23%
Readers by discipline Count As %
Agricultural and Biological Sciences 14 23%
Neuroscience 13 21%
Medicine and Dentistry 7 11%
Biochemistry, Genetics and Molecular Biology 6 10%
Engineering 2 3%
Other 3 5%
Unknown 17 27%