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X Demographics
Mendeley readers
Attention Score in Context
| Title |
High glucose induces Smad activation via the transcriptional coregulator p300 and contributes to cardiac fibrosis and hypertrophy
|
|---|---|
| Published in |
Cardiovascular Diabetology, May 2014
|
| DOI | 10.1186/1475-2840-13-89 |
| Pubmed ID | |
| Authors |
Antoinette Bugyei-Twum, Andrew Advani, Suzanne L Advani, Yuan Zhang, Kerri Thai, Darren J Kelly, Kim A Connelly |
| Abstract |
Despite advances in the treatment of heart failure, mortality remains high, particularly in individuals with diabetes. Activated transforming growth factor beta (TGF-β) contributes to the pathogenesis of the fibrotic interstitium observed in diabetic cardiomyopathy. We hypothesized that high glucose enhances the activity of the transcriptional co-activator p300, leading to the activation of TGF-β via acetylation of Smad2; and that by inhibiting p300, TGF-β activity will be reduced and heart failure prevented in a clinically relevant animal model of diabetic cardiomyopathy. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 75 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 75 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 16 | 21% |
| Researcher | 11 | 15% |
| Student > Master | 11 | 15% |
| Student > Doctoral Student | 6 | 8% |
| Other | 5 | 7% |
| Other | 11 | 15% |
| Unknown | 15 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 23 | 31% |
| Medicine and Dentistry | 15 | 20% |
| Agricultural and Biological Sciences | 9 | 12% |
| Pharmacology, Toxicology and Pharmaceutical Science | 2 | 3% |
| Nursing and Health Professions | 2 | 3% |
| Other | 4 | 5% |
| Unknown | 20 | 27% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 May 2014.
All research outputs
#20,229,658
of 22,755,127 outputs
Outputs from Cardiovascular Diabetology
#1,206
of 1,371 outputs
Outputs of similar age
#193,255
of 227,397 outputs
Outputs of similar age from Cardiovascular Diabetology
#14
of 17 outputs
Altmetric has tracked 22,755,127 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,371 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.7. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 227,397 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 17 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.