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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Small molecule kinase inhibitor LRRK2-IN-1 demonstrates potent activity against colorectal and pancreatic cancer through inhibition of doublecortin-like kinase 1
|
|---|---|
| Published in |
Molecular Cancer, May 2014
|
| DOI | 10.1186/1476-4598-13-103 |
| Pubmed ID | |
| Authors |
Nathaniel Weygant, Dongfeng Qu, William L Berry, Randal May, Parthasarathy Chandrakesan, Daniel B Owen, Sripathi M Sureban, Naushad Ali, Ralf Janknecht, Courtney W Houchen |
| Abstract |
Doublecortin-like kinase 1 (DCLK1) is emerging as a tumor specific stem cell marker in colorectal and pancreatic cancer. Previous in vitro and in vivo studies have demonstrated the therapeutic effects of inhibiting DCLK1 with small interfering RNA (siRNA) as well as genetically targeting the DCLK1+ cell for deletion. However, the effects of inhibiting DCLK1 kinase activity have not been studied directly. Therefore, we assessed the effects of inhibiting DCLK1 kinase activity using the novel small molecule kinase inhibitor, LRRK2-IN-1, which demonstrates significant affinity for DCLK1. |
X Demographics
The data shown below were collected from the profiles of 6 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 1 | 17% |
| Mexico | 1 | 17% |
| Unknown | 4 | 67% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Practitioners (doctors, other healthcare professionals) | 3 | 50% |
| Scientists | 2 | 33% |
| Members of the public | 1 | 17% |
Mendeley readers
The data shown below were compiled from readership statistics for 91 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| India | 1 | 1% |
| United States | 1 | 1% |
| Australia | 1 | 1% |
| Unknown | 88 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 27 | 30% |
| Student > Bachelor | 12 | 13% |
| Student > Ph. D. Student | 11 | 12% |
| Student > Master | 11 | 12% |
| Other | 5 | 5% |
| Other | 12 | 13% |
| Unknown | 13 | 14% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 28 | 31% |
| Biochemistry, Genetics and Molecular Biology | 19 | 21% |
| Medicine and Dentistry | 14 | 15% |
| Chemistry | 4 | 4% |
| Immunology and Microbiology | 3 | 3% |
| Other | 11 | 12% |
| Unknown | 12 | 13% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 May 2014.
All research outputs
#6,837,459
of 22,755,127 outputs
Outputs from Molecular Cancer
#487
of 1,717 outputs
Outputs of similar age
#66,194
of 227,400 outputs
Outputs of similar age from Molecular Cancer
#11
of 48 outputs
Altmetric has tracked 22,755,127 research outputs across all sources so far. This one has received more attention than most of these and is in the 69th percentile.
So far Altmetric has tracked 1,717 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.7. This one has gotten more attention than average, scoring higher than 71% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 227,400 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 70% of its contemporaries.
We're also able to compare this research output to 48 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 77% of its contemporaries.