Title |
Repositioning: the fast track to new anti-malarial medicines?
|
---|---|
Published in |
Malaria Journal, April 2014
|
DOI | 10.1186/1475-2875-13-143 |
Pubmed ID | |
Authors |
Julie Lotharius, Francisco Javier Gamo-Benito, Iñigo Angulo-Barturen, Julie Clark, Michele Connelly, Santiago Ferrer-Bazaga, Tanya Parkinson, Pavithra Viswanath, Balachandra Bandodkar, Nikhil Rautela, Sowmya Bharath, Sandra Duffy, Vicky M Avery, Jörg J Möhrle, R Kiplin Guy, Timothy Wells |
Abstract |
Repositioning of existing drugs has been suggested as a fast track for developing new anti-malarial agents. The compound libraries of GlaxoSmithKline (GSK), Pfizer and AstraZeneca (AZ) comprising drugs that have undergone clinical studies in other therapeutic areas, but not achieved approval, and a set of US Food and Drug Administration (FDA)-approved drugs and other bio-actives were tested against Plasmodium falciparum blood stages. |
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