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Generation and characterization of new monoclonal antibodies targeting the PHF1 and AT8 epitopes on human tau

Overview of attention for article published in Acta Neuropathologica Communications, July 2017
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (64th percentile)

Mentioned by

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1 tweeter
patent
3 patents

Citations

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31 Dimensions

Readers on

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53 Mendeley
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Title
Generation and characterization of new monoclonal antibodies targeting the PHF1 and AT8 epitopes on human tau
Published in
Acta Neuropathologica Communications, July 2017
DOI 10.1186/s40478-017-0458-0
Pubmed ID
Authors

Kevin H. Strang, Marshall S. Goodwin, Cara Riffe, Brenda D. Moore, Paramita Chakrabarty, Yona Levites, Todd E. Golde, Benoit I. Giasson

Abstract

Tauopathies are a group of neurodegenerative disorders, including Alzheimer's disease, defined by the presence of brain pathological inclusions comprised of abnormally aggregated and highly phosphorylated tau protein. The abundance of brain tau aggregates correlates with disease severity and select phospho-tau epitopes increase at early stages of disease. We generated and characterized a series of novel monoclonal antibodies directed to tau phosphorylated at several of these phospho-epitopes, including Ser396/Ser404, Ser404 and Thr205. We also generated phosphorylation independent antibodies against amino acid residues 193-211. We show that most of these antibodies are highly specific for tau and strongly recognize pathological inclusions in human brains and in a transgenic mouse model of tauopathy. They also reveal epitope-specific differences in the biochemical properties of Alzheimer's disease sarkosyl-insoluble tau. These new reagents will be useful for investigating the progression of tau pathology and further as tools to target the cellular transmission of tau pathology.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 53 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 53 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 14 26%
Student > Bachelor 8 15%
Student > Master 8 15%
Professor > Associate Professor 5 9%
Researcher 4 8%
Other 7 13%
Unknown 7 13%
Readers by discipline Count As %
Neuroscience 18 34%
Biochemistry, Genetics and Molecular Biology 6 11%
Medicine and Dentistry 6 11%
Agricultural and Biological Sciences 6 11%
Pharmacology, Toxicology and Pharmaceutical Science 4 8%
Other 4 8%
Unknown 9 17%

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 June 2022.
All research outputs
#6,574,100
of 21,708,871 outputs
Outputs from Acta Neuropathologica Communications
#870
of 1,290 outputs
Outputs of similar age
#100,685
of 289,862 outputs
Outputs of similar age from Acta Neuropathologica Communications
#1
of 1 outputs
Altmetric has tracked 21,708,871 research outputs across all sources so far. This one has received more attention than most of these and is in the 68th percentile.
So far Altmetric has tracked 1,290 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 12.4. This one is in the 32nd percentile – i.e., 32% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 289,862 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 64% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them